ArticleBMC genomics2018
Whole-genome sequencing of Aspergillus tubingensis G131 and overview of its secondary metabolism potential.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Cross-talk within plant niches: endophytic and arbuscular mycorrhizal fungi for sustainable crop production.FEMS microbiology reviews · 2026Review
- Reconstruction of a genome-scale metabolic model and in-silico flux analysis of Aspergillus tubingensis: a non-mycotoxinogenic citric acid-producing fungus.Biotechnology for biofuels and bioproducts · 2024Article
- Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex.Nature communications · 2023Article
- A Mad7 System for Genetic Engineering of Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2022Article
- Epigenetic Manipulation Induced Production of Immunosuppressive Chromones and Cytochalasins from the Mangrove Endophytic FungusMarine drugs · 2022Article
- In Vitro Phytobiological Investigation of Bioactive Secondary Metabolites from theMolecules (Basel, Switzerland) · 2022Article
- New Antioxidant Active Packaging Films Based on Yeast Cell Wall and Naphtho-γ-Pyrone Extract.Polymers · 2022Article
- Unraveling the Genome Sequence of Plant Growth PromotingJournal of fungi (Basel, Switzerland) · 2022Article
- Genomic Analysis and Assessment of Melanin Synthesis inJournal of fungi (Basel, Switzerland) · 2021Article
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- Impact of Spray-Drying on Biological Properties of Chitosan Matrices Supplemented with Antioxidant Fungal Extracts for Wine Applications.Current microbiology · 2020Article
- Naphtho-Gamma-Pyrones Produced byBiomolecules · 2019Article
- Genomic characteristics and comparative genomics analysis of the endophytic fungus Sarocladium brachiariae.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlack Aspergilli represent one of the most important fungal resources of primary and secondary metabolites for biotechnological industry. Having several black Aspergilli sequenced genomes should allow targeting the production of certain metabolites with bioactive properties.
resultsIn this study, we report the draft genome of a black Aspergilli, A. tubingensis G131, isolated from a French Mediterranean vineyard. This 35 Mb genome includes 10,994 predicted genes. A genomic-based discovery identifies 80 secondary metabolites biosynthetic gene clusters. Genomic sequences of these clusters were blasted on 3 chosen black Aspergilli genomes: A. tubingensis CBS 134.48, A. niger CBS 513.88 and A. kawachii IFO 4308. This comparison highlights different levels of clusters conservation between the four strains. It also allows identifying seven unique clusters in A. tubingensis G131. Moreover, the putative secondary metabolites clusters for asperazine and naphtho-gamma-pyrones production were proposed based on this genomic analysis. Key biosynthetic genes required for the production of 2 mycotoxins, ochratoxin A and fumonisin, are absent from this draft genome. Even if intergenic sequences of these mycotoxins biosynthetic pathways are present, this could not lead to the production of those mycotoxins by A. tubingensis G131.
conclusionsFunctional and bioinformatics analyses of A. tubingensis G131 genome highlight its potential for metabolites production in particular for TAN-1612, asperazine and naphtho-gamma-pyrones presenting antioxidant, anticancer or antibiotic properties.
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