Evidence map›Paper›PMID 29702624›Full record

ReviewAntioxidants (Basel, Switzerland)2018

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies.

Caroline Gaucher, Ariane Boudier, Justine Bonetti, Igor Clarot, Pierre Leroy, Marianne Parent

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 316 citations in OpenAlex.

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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Caroline GaucherUniversité de Lorraine, CITHEFOR, F-54000 Nancy, France. caroline.gaucher@univ-lorraine.fr.ORCID 0000-0002-0886-5522
Ariane BoudierUniversité de Lorraine, CITHEFOR, F-54000 Nancy, France. ariane.boudier@univ-lorraine.fr.
Justine BonettiUniversité de Lorraine, CITHEFOR, F-54000 Nancy, France. justine.bonetti@univ-lorraine.fr.
Igor ClarotUniversité de Lorraine, CITHEFOR, F-54000 Nancy, France. igor.clarot@univ-lorraine.fr.
Pierre LeroyUniversité de Lorraine, CITHEFOR, F-54000 Nancy, France. pierre.leroy@univ-lorraine.fr.
Marianne ParentUniversité de Lorraine, CITHEFOR, F-54000 Nancy, France. marianne.parent@univ-lorraine.fr.ORCID 0000-0002-7447-9806
Cibles thérapeutiques, formulation et expertise préclinique du médicament

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review aims to bring out some lesser-known aspects of GSH, for example, as an emerging tool in nanotechnologies to achieve targeted drug delivery. After recalling the biochemistry of GSH, including its metabolism pathways and redox properties, its involvement in cellular redox homeostasis and signaling is described. Analytical methods for the dosage and localization of GSH or glutathiolated proteins are also covered. Finally, the various therapeutic strategies to replenish GSH stocks are discussed, in parallel with its use as an addressing molecule in drug delivery.

Indexed as

antioxidantglutathionenanotechnologiesredox signalingrepletiontargeted drug delivery

Identifiers

PMID29702624
PMCPMC5981248
OpenAlexW2801663757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.