Evidence map›Paper›PMID 29702529›Full record

ArticlePancreas

The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

James L Abbruzzese, Dana K Andersen, Carl A K Borrebaeck, Suresh T Chari, Eithne Costello, Zobeida Cruz-Monserrate, Guido Eibl, Edgar G Engleman, William E Fisher, Aida Habtezion and 9 more

Open access · greenAbstract readConference Proceedings
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. A review of physical activity in pancreatic ductal adenocarcinoma: Epidemiology, intervention, animal models, and clinical trials.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Dietary Patterns of Insulinemia, Inflammation and Glycemia, and Pancreatic Cancer Risk: Findings from the Women's Health Initiative.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  18. Hyperinsulinemia in Obesity, Inflammation, and Cancer.Diabetes & metabolism journal · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

James L Abbruzzese
Dana K Andersen
Carl A K Borrebaeck
Suresh T Chari
Eithne Costello
Zobeida Cruz-Monserrate
Guido Eibl
Edgar G Engleman
William E Fisher
Aida Habtezion
Seung K Kim
Murray Korc
Craig Logsdon
Costas A Lyssiotis
Stephen J Pandol
Anil Rustgi
Bruce M Wolfe
Lei Zheng
Alvin C Powers
Cedars-Sinai Medical Center · USIndiana University Health · USLund University · SEOregon Health & Science University · USThe University of Texas MD Anderson Cancer Center · USNational Institutes of Health · USUniversity of California, Los Angeles · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
The Prrx-1 transcription factor in pancreatic ductal biologyR01DK060694 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CHANDWANI, ROHIT, RUSTGI, ANIL K · 2002 to 2025
$8.3M
Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2014 to 2018
$8.1M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic CancerU01DK108300 · NIDDK · STANFORD UNIVERSITY · PI Sohail Z Husain, Walter Gwang-Up Park · 2015 to 2026
$6.3M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2012 to 2016
$6.2M
DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCERU01DK108326 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FISHER, WILLIAM E · 2015 to 2024
$5.2M
Novel aspects of Epithelial-Mesenchymal Transition(EMT)in pancreatic cancerR01CA075059 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KORC, MURRAY · 1997 to 2018
$4.3M
Reconstituting human pancreatic cancer development for translational researchR01CA211927 · NCI · STANFORD UNIVERSITY · PI KIM, SEUNG K · 2017 to 2019
$1.5M
NCI NIH HHS P01 CA163200NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA075059NCI NIH HHS R01 CA211927NIAAA NIH HHS P50 AA011999NIDDK NIH HHS P01 DK098108NIDDK NIH HHS R01 DK060694NIDDK NIH HHS U01 DK108300NIDDK NIH HHS U01 DK108323NIDDK NIH HHS U01 DK108326NIH HHS P01 CA163200NIH HHS P50 CA014236NIH HHS R01 CA075059NIH HHS R01 DK060694NIH HHS U01 DK 108323
6 · The paper itself

Abstract

A workshop on "The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities" was held by the National Institute of Diabetes and Digestive and Kidney Diseases on October 12, 2017. The purpose of the workshop was to explore the relationship and possible mechanisms of the increased risk of pancreatic ductal adenocarcinoma (PDAC) related to diabetes, the role of altered intracellular energy metabolism in PDAC, the mechanisms and biomarkers of diabetes caused by PDAC, the mechanisms of the increased risk of PDAC associated with obesity, and the role of inflammatory events and mediators as contributing causes of the development of PDAC. Workshop faculty reviewed the state of the current knowledge in these areas and made recommendations for future research efforts. Further knowledge is needed to elucidate the basic mechanisms contributing to the role of hyperinsulinemia, hyperglycemia, adipokines, and acute and chronic inflammatory events on the development of PDAC.

Indexed as

Biomedical ResearchCarcinoma, Pancreatic DuctalComorbidityDiabetes MellitusEnergy MetabolismHumansInflammationNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.)ObesityPancreatic NeoplasmsRisk FactorsUnited States

Identifiers

PMID29702529
PMCPMC6361376
OpenAlexW2910791465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.