Evidence map›Paper›PMID 29702100›Full record

ArticleExperimental eye research2018

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca

Marit Lippestad, Robin R Hodges, Tor P Utheim, Charles N Serhan, Darlene A Dartt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Purinergic agonists increase [CaAmerican journal of physiology. Cell physiology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  10. Article
  11. RvE1 uses the LTBThe ocular surface · 2020
    Article
  12. Review
  13. Resolvin D2 elevates cAMP to increase intracellular [CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Marit LippestadSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
Robin R HodgesSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Tor P UtheimSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Department of Plastic and Reconstructive Surgery, University of Oslo, Oslo, Norway.
Charles N SerhanCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Darlene A DarttSchepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Department of Plastic and Reconstructive Surgery, University of Oslo, Oslo, Norway. Electronic address: Darlene_dartt@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USOslo University Hospital · NOBrigham and Women's Hospital · US

Funding

Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its ResolutionR01EY019470 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A · 2009 to 2023
$7.4M
BLOOD CELL LIPOXYGENASE PRODUCTS: FORMATION AND ACTIONR01GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 1992 to 2020
$4.9M
CONTROL OF CONJUNCTIVAL GOBLET CELL MUCOUS PRODUCTIONR01EY009057 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A · 1991 to 2009
$3.2M
NEI NIH HHS R01 EY009057NEI NIH HHS R01 EY019470NIGMS NIH HHS R01 GM038765
6 · The paper itself

Abstract

Glycoconjugate mucin secretion from conjunctival goblet cells is tightly regulated by nerves and specialized pro-resolving mediators (SPMs) to maintain ocular surface health. Here we investigated the actions of the SPM resolvin E1 (RvE1) on cultured rat conjunctival goblet cell glycoconjugate secretion and intracellular [Ca

Indexed as

AnimalsCalciumCells, CulturedConjunctivaCytoplasmDose-Response Relationship, DrugEicosapentaenoic AcidFura-2Goblet CellsMaleMAP Kinase Signaling SystemMucinsPhospholipase DPhospholipases A2RatsRats, Sprague-Dawley5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acidCalciumEicosapentaenoic AcidFura-2fura-2-amMucinsPhospholipase DPhospholipases A2Type C PhospholipasesAllergyConjunctivaGoblet cellsInflammationPro-resolving mediators

Identifiers

PMID29702100
PMCPMC6488018
OpenAlexW2802490127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.