Evidence map›Paper›PMID 29701961›Full record

ArticleJournal of the American Chemical Society2018

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Maho Morita, Yue Hao, Jouni K Jokela, Debosmita Sardar, Zhenjian Lin, Kaarina Sivonen, Satish K Nair, Eric W Schmidt

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. De Novo Discovery of Prenylated Macrocyclic Peptide Ligands.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Biosynthesis of guanidine-containing natural products in cyanobacteria.Journal of industrial microbiology & biotechnology · 2024
    Review
  7. Article
  8. Article
  9. Promiscuous Enzymes for Residue-Specific Peptide and Protein Late-Stage Functionalization.Chembiochem : a European journal of chemical biology · 2023
    Review
  10. Review
  11. A cytosolic bifunctional geranyl/farnesyl diphosphate synthase provides MVA-derived GPP for geraniol biosynthesis in rose flowers.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Biochemical characterization of a cyanobactin arginine-Chemical communications (Cambridge, England) · 2022
    Article
  16. Catalysts for the Enzymatic Lipidation of Peptides.Accounts of chemical research · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Recent advances in biocatalytic derivatization of L-tyrosine.Applied microbiology and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maho MoritaDepartment of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
Yue HaoDepartment of Biochemistry, Institute for Genomic Biology, and Center for Biophysics and Quantitative Biology, Department of Biochemistry , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.
Jouni K JokelaDepartment of Microbiology , University of Helsinki , Helsinki 00014 , Finland.ORCID 0000-0001-5096-3575
Debosmita SardarDepartment of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
Zhenjian LinDepartment of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
Kaarina SivonenDepartment of Microbiology , University of Helsinki , Helsinki 00014 , Finland.ORCID 0000-0002-2904-0458
Satish K NairDepartment of Biochemistry, Institute for Genomic Biology, and Center for Biophysics and Quantitative Biology, Department of Biochemistry , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.ORCID 0000-0003-1790-1334
Eric W SchmidtDepartment of Medicinal Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.ORCID 0000-0001-5839-694X

Funding

Structural /Mechanistic Study of Lantibiotic Biosynthetic Enzymes & AutoimmunityR01GM079038 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NAIR, SATISH K · 2006 to 2023
$3.7M
Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
Directed posttranslational modifications for drug design and discoveryR01GM102602 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2013 to 2016
$1.4M
NIGMS NIH HHS R01 GM079038NIGMS NIH HHS R01 GM102602NIGMS NIH HHS R35 GM122521
6 · The paper itself

Abstract

Prenylation is a widespread modification that improves the biological activities of secondary metabolites. This reaction also represents a key modification step in biosyntheses of cyanobactins, a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by cyanobacteria. In cyanobactins, amino acids are commonly isoprenylated by ABBA prenyltransferases that use C

Indexed as

Protein Processing, Post-TranslationalCyanobacteriaGeranyltranstransferasePeptides, CyclicTyrosinecyanobactinsGeranyltranstransferasePeptides, CyclicTyrosine

Identifiers

PMID29701961
PMCPMC6242345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.