Evidence map›Paper›PMID 29701957›Full record

ArticleACS chemical neuroscience2018

A Novel M

Jerri M Rook, Jeanette L Bertron, Hyekyung P Cho, Pedro M Garcia-Barrantes, Sean P Moran, James T Maksymetz, Kellie D Nance, Jonathan W Dickerson, Daniel H Remke, Sichen Chang and 7 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 64 citations in OpenAlex.

  1. ACS medicinal chemistry letters · 2026
    Article
  2. Review
  3. Discovery of VU6052254: A Novel, Potent MACS chemical neuroscience · 2025
    Article
  4. Discovery of a Novel spACS medicinal chemistry letters · 2025
    Article
  5. Application of Deuterium in an MACS chemical neuroscience · 2025
    Article
  6. Review
  7. Review
  8. Discovery of VU0467319: an MACS chemical neuroscience · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. MProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. MScience signaling · 2022
    Article
  14. Article
  15. Clinical and Preclinical Evidence for MNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  16. Review
  17. MPharmacology research & perspectives · 2022
    Article
  18. Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments.International journal of molecular sciences · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Jerri M Rook
Jeanette L Bertron
Hyekyung P Cho
Pedro M Garcia-Barrantes
James T Maksymetz
Jonathan W Dickerson
Daniel H Remke
Sichen Chang
Joel M Harp
Anna L Blobaum
Colleen M Niswender
Carrie K Jones
Shaun R Stauffer
P Jeffrey Conn
Vanderbilt University · US

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALLACE, MARK THOMAS · 2015 to 2019
$7.1M
Safety and tolerability testing of VU0467319: an M1 PAM for clinical developmentU19MH106839 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2015 to 2017
$5.3M
Selective M1 mAChR allosteric modulators for the treatment of schizophreniaR01MH082867 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2008 to 2017
$3.7M
mGlu Allosteric Modulation in Neurodegenerative DiseasesR01AG051626 · NIA · VANDERBILT UNIVERSITY · PI ROOK, JERRI MICHELLE · 2016 to 2020
$2.0M
Role of Phospholipase D in M1 Allosteric Modulation of Synaptic Plasticity: Implications for the Treatment of SchizophreniaF31MH114368 · NIMH · VANDERBILT UNIVERSITY · PI MORAN, SEAN PATRICK · 2017 to 2019
$71k
NIA NIH HHS R01 AG051626NICHD NIH HHS U54 HD083211NIMH NIH HHS F31 MH114368NIMH NIH HHS R01 MH082867NIMH NIH HHS U19 MH106839
6 · The paper itself

Abstract

Selective activation of the M

Indexed as

Allosteric RegulationAnimalsAntipsychotic AgentsCHO CellsCognitionCognitive DysfunctionConditioning, PsychologicalCricetulusExploratory BehaviorFearMiceMorpholinesPrefrontal CortexPyrazolesRatsRisperidoneAntipsychotic AgentsMorpholinesPyrazolesRisperidoneVU0486846agonistago-PAMcognitionM1muscarinic acetylcholine receptorpositive allosteric modulatorschizophrenia

Identifiers

PMID29701957
PMCPMC6146057
OpenAlexW2801645749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.