ArticleThe Journal of clinical psychiatry
Childhood Adversity and Schizophrenia: The Protective Role of Resilience in Mental and Physical Health and Metabolic Markers.
Article in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Outcomes of Randomized Clinical Trials of Interventions to Enhance Social, Emotional, and Spiritual Components of Wisdom: A Systematic Review and Meta-analysis.JAMA psychiatry · 2020Pooled it
- Caregiver Psychopathology, Resilience, and Their Associations with Social-Emotional Challenges of Young Children Affected by Armed Conflict in Colombia.Child psychiatry and human development · 2026Article
- Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia.BMC psychiatry · 2025Article
- The relationship between self-esteem and social avoidance among university students: chain mediating effects of resilience and social distress.BMC psychology · 2025Article
- Impacts of age and environment on postnatal microglial activity: Consequences for cognitive function following early life adversity.PloS one · 2024Article
- Construction and verification of aggressive behavior risk prediction model in stable patients with schizophrenia.BMC psychiatry · 2023Article
- Article
- Review of Major Social Determinants of Health in Schizophrenia-Spectrum Disorders: II. Assessments.Schizophrenia bulletin · 2023Article
- Self-compassion, but not compassion toward others, is associated with better physical health: A cross-sectional study.Schizophrenia research · 2023Article
- Use of virtual meeting and survey technology to assess Covid-19-related mental well-being of healthcare workers.Ethics, medicine, and public health · 2023Article
- Heterogeneity of resilience and the curvilinear relationship between childhood trauma and resilience among people with schizophrenia.Frontiers in psychiatry · 2023Article
- Adverse childhood experiences in patients with schizophrenia: related factors and clinical implications.Frontiers in psychiatry · 2023Article
- The relationship between intolerance of uncertainty, coping style, resilience, and anxiety during the COVID-19 relapse in freshmen: A moderated mediation model.Frontiers in psychiatry · 2023Article
- Protective and Vulnerability Factors of Municipal Workers' Mental Health: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Cross-Cultural Comparison of ICD-11 Adjustment Disorder Prevalence and Its Risk Factors in Japanese and Lithuanian Adolescents.Brain sciences · 2022Article
- Metabolic disturbances, hemoglobin A1c, and social cognition impairment in Schizophrenia spectrum disorders.Translational psychiatry · 2022Article
- An Integrated Account of Expert Perspectives on Functioning in Schizophrenia.Journal of clinical medicine · 2021Article
- Sex differences and psychological stress: responses to the COVID-19 pandemic in China.BMC public health · 2021Article
- Article
- Metabolic Dysregulation and Psychosocial Stress in Patients with Schizophrenia Spectrum Disorders: A Case-Control Study.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the impact of childhood adversity and current (adulthood) resilience on mental and physical health and markers of metabolic function among adults with schizophrenia and nonpsychiatric comparison participants (NCs).
methodsWe conducted a cross-sectional study of 114 participants with schizophrenia (DSM-IV-TR criteria) and 101 NCs aged 26-65 years during 2012-2017. Sociodemographic, clinical, and laboratory measures were examined. Childhood Trauma Questionnaire was used to retrospectively assess emotional abuse/neglect, physical abuse/neglect, and sexual abuse experienced during childhood. Connor-Davidson Resilience Scale was employed to measure resilience.
resultsPersons with schizophrenia reported more severe childhood trauma, lower resilience, and worse mental and physical health and had worse metabolic biomarker levels than NCs. Trauma severity correlated with worse depression in the NCs (r = 0.34), but not in the schizophrenia group (r = 0.02). In both groups, trauma severity was associated with worse physical well-being, higher fasting insulin levels, and greater insulin resistance (P ≤ .02). Notably, resilience appeared to counteract effects of trauma and diagnosis on mental and physical health. The schizophrenia subgroup with high resilience and severe trauma reported mental and physical well-being and had glycosylated hemoglobin levels and insulin resistance scores that were comparable to those of NCs with low resilience and severe trauma.
conclusionsTo our knowledge, this is the first study to quantitatively assess effects of both childhood trauma and resilience in schizophrenia on health, notably metabolic function. Interventions to bolster resilience in the general population and in people with schizophrenia may improve outcomes for those with a history of childhood adversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.