Evidence map›Paper›PMID 29701935›Full record

ArticleThe Journal of clinical psychiatry

Risk Factors for Overdose in Treatment-Seeking Youth With Substance Use Disorders.

Amy M Yule, Nicholas W Carrellas, Maura Fitzgerald, James W McKowen, Jessica E Nargiso, Brandon G Bergman, John F Kelly, Timothy E Wilens

Open access · greenAbstract read
In one paragraph

Article in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Risk Factors for Drug Overdose in Young People: A Systematic Review of the Literature.Journal of child and adolescent psychopharmacology · 2019
    Pooled it
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  7. The Association of Stigma, School, and Family Factors with Patterns of Substance Use Among LGBTQ Youth.Prevention science : the official journal of the Society for Prevention Research · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amy M YuleAddiction Recovery Management Services (ARMS), Massachusetts General Hospital, 151 Merrimac St, 6th Fl, Boston, MA 02114. ayule@partners.org.
Nicholas W CarrellasPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Maura FitzgeraldPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
James W McKowenPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jessica E NargisoAddiction Recovery Management Service, Center for Addiction Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Brandon G BergmanAddiction Recovery Management Service, Center for Addiction Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
John F KellyAddiction Recovery Management Service, Center for Addiction Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Timothy E WilensPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Massachusetts General Hospital · US

Funding

AACAP Physician Scientist Program in Substance UseK12DA000357 · NIDA · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · PI Kevin M. Gray · 1998 to 2026
$29.1M
Mentoring in Patient-Oriented Addiction ResearchK24AA022136 · NIAAA · MASSACHUSETTS GENERAL HOSPITAL · PI KELLY, JOHN F. · 2014 to 2023
$1.8M
Funded extension request for "Expanding recovery support for emerging adults with alcohol use disorder: Training in the science of social network sites"K23AA025707 · NIAAA · MASSACHUSETTS GENERAL HOSPITAL · PI BERGMAN, BRANDON G. · 2018 to 2023
$1.0M
NIAAA NIH HHS K23 AA025707NIAAA NIH HHS K24 AA022136NIDA NIH HHS K12 DA000357
6 · The paper itself

Abstract

objectiveOverdoses (ODs) are among the leading causes of death in youth with substance use disorders (SUDs). Our aim was to identify the prevalence of OD and characteristics associated with a history of OD in youth presenting for SUD outpatient care.

methodsA systematic retrospective medical record review was conducted of consecutive psychiatric and SUD evaluations for patients aged 16 to 26 years with DSM-IV-TR criteria SUD at entry into an outpatient SUD treatment program for youth between January 2012 and June 2013. Unintentional OD was defined as substance use without intention of self-harm that was associated with a significant impairment in level of consciousness. Intentional OD was defined as ingestion of a substance that was reported as a suicide attempt. T tests, Pearson χ² tests, and Fisher exact tests were performed to evaluate characteristics associated with a history of OD.

resultsWe examined the medical records of 200 patients (157 males and 43 females) with a mean ± SD age of 20.2 ± 2.8 years. At intake, 58 patients (29%) had a history of OD, and 62% of those patients had a history of unintentional OD only (n = 36). Youth with ≥ 2 SUDs were 3 times more likely to have a history of OD compared to youth with 1 SUD (all P < .05). Compared to those without a history of OD, those with an OD were more likely to be female and have lifetime histories of alcohol, cocaine, amphetamine, anxiety, depressive, and/or eating disorders (all P < .05).

conclusionsHigh rates of OD exist in treatment-seeking youth with SUD. OD was associated with more SUDs and psychiatric comorbidity.

Indexed as

AdolescentAdultComorbidityDrug OverdoseFemaleHumansMaleMental DisordersPatient Acceptance of Health CarePrevalenceRetrospective StudiesRisk FactorsSubstance-Related DisordersUnited StatesYoung Adult

Identifiers

PMID29701935
PMCPMC6043357
OpenAlexW2802120853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.