Evidence map›Paper›PMID 29701909›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

The impact of direct-acting antiviral agents on liver and kidney transplant costs and outcomes.

D A Axelrod, M A Schnitzler, T Alhamad, F Gordon, R D Bloom, G P Hess, H Xiao, M Nazzal, D L Segev, V R Dharnidharka and 6 more

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Opioids and Kidney Transplantation.Seminars in nephrology · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Center-level trends in utilization of HCV-exposed donors for HCV-uninfected kidney and liver transplant recipients in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  13. Optimal timing of hepatitis C treatment among HIV/HCV coinfected ESRD patients: Pre- vs posttransplant.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  14. Mortality and Kidney Transplantation Outcomes Among Hepatitis C Virus-Seropositive Maintenance Dialysis Patients: A Retrospective Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Population level outcomes and cost-effectiveness of hepatitis C treatment pre- vs postkidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

D A AxelrodLahey Hospital & Medical Center, Burlington, MA, USA.
M A SchnitzlerSaint Louis University Center for Abdominal Transplantation, St. Louis, MO, USA.
T AlhamadWashington University, St. Louis, MO, USA.
F GordonLahey Hospital & Medical Center, Burlington, MA, USA.
R D BloomUniversity of Pennsylvania, Philadelphia, PA, USA.
G P HessSymphony Health, Conshohocken, PA, USA.
H XiaoSaint Louis University Center for Abdominal Transplantation, St. Louis, MO, USA.
M NazzalSaint Louis University Center for Abdominal Transplantation, St. Louis, MO, USA.
D L SegevJohns Hopkins University, Baltimore, MD, USA.
V R DharnidharkaWashington University, St. Louis, MO, USA.
A S NaikUniversity of Michigan, Ann Arbor, MI, USA.
N N LamUniversity of Alberta, Edmonton, AB, Canada.
R OusephSaint Louis University Center for Abdominal Transplantation, St. Louis, MO, USA.
B L KasiskeHennepin County Medical Center, Minneapolis, MN, USA.
C M DurandJohns Hopkins University, Baltimore, MD, USA.
K L LentineSaint Louis University Center for Abdominal Transplantation, St. Louis, MO, USA.

Funding

Choosing Immune Suppression in Renal Transplantation by Efficacy and MorbidityR01DK102981 · NIDDK · WASHINGTON UNIVERSITY · PI DHARNIDHARKA, VIKAS R. · 2014 to 2018
$1.9M
NIDDK NIH HHS R01 DK102981NIDDK NIH HHS R01DK102981
6 · The paper itself

Abstract

Direct-acting antiviral medications (DAAs) have revolutionized care for hepatitis C positive (HCV+) liver (LT) and kidney (KT) transplant recipients. Scientific Registry of Transplant Recipients registry data were integrated with national pharmaceutical claims (2007-2016) to identify HCV treatments before January 2014 (pre-DAA) and after (post-DAA), stratified by donor (D) and recipient (R) serostatus and payer. Pre-DAA, 18% of HCV+ LT recipients were treated within 3 years and without differences by donor serostatus or payer. Post-DAA, only 6% of D-/R+ recipients, 19.8% of D+/R+ recipients with public insurance, and 11.3% with private insurance were treated within 3 years (P < .0001). LT recipients treated for HCV pre-DAA experienced higher rates of graft loss (adjusted hazard ratio [aHR]

Indexed as

Graft SurvivalAdolescentAdultAgedAntiviral AgentsFemaleFollow-Up StudiesHepacivirusHepatitis CHumansKidney TransplantationLiver TransplantationMaleMiddle AgedPrognosisRegistriesAntiviral Agentsclinical research/practiceeconomicshealth services and outcomes researchinfection and infectious agents - viral: hepatitis Ckidney (allograft) function/dysfunctionkidney transplantation/nephrologyliver allograft function/dysfunctionliver transplantation/hepatologypatient survival

Identifiers

PMID29701909
PMCPMC6409105

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.