ArticleMolecular biology and evolution2018
Ancestral Function and Diversification of a Horizontally Acquired Oomycete Carboxylic Acid Transporter.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- A structural window into the evolution of secondary transport mechanisms.Nature structural & molecular biology · 2025Article
- Horizontal Gene Transfer in Plants and Implications for Biotechnology.Plant-environment interactions (Hoboken, N.J.) · 2025Review
- Duplication and neofunctionalization of a horizontally transferred xyloglucanase as a facet of the Red Queen coevolutionary dynamic.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- Duplication and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen co-evolutionary dynamic.bioRxiv : the preprint server for biology · 2023Article
- Global patterns and rates of habitat transitions across the eukaryotic tree of life.Nature ecology & evolution · 2022Article
- Resurrecting Enzymes by Ancestral Sequence Reconstruction.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Uncovering the Role of Metabolism in Oomycete-Host Interactions Using Genome-Scale Metabolic Models.Frontiers in microbiology · 2021Review
- Phylotranscriptomics of the Pentapetalae Reveals Frequent Regulatory Variation in Plant Local Responses to the Fungal PathogenThe Plant cell · 2020Article
- Carbon assimilation profiles of mucoralean fungi show their metabolic versatility.Scientific reports · 2019Article
- Metabolic Model of themBio · 2019Article
- Environment-dependent fitness gains can be driven by horizontal gene transfer of transporter-encoding genes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Lateral transfers of large DNA fragments spread functional genes among grasses.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer (HGT) can equip organisms with novel genes, expanding the repertoire of genetic material available for evolutionary innovation and allowing recipient lineages to colonize new environments. However, few studies have characterized the functions of HGT genes experimentally or examined postacquisition functional divergence. Here, we report the use of ancestral sequence reconstruction and heterologous expression in Saccharomyces cerevisiae to examine the evolutionary history of an oomycete transporter gene family that was horizontally acquired from fungi. We demonstrate that the inferred ancestral oomycete HGT transporter proteins and their extant descendants transport dicarboxylic acids which are intermediates of the tricarboxylic acid cycle. The substrate specificity profile of the most ancestral protein has largely been retained throughout the radiation of oomycetes, including in both plant and animal pathogens and in a free-living saprotroph, indicating that the ancestral HGT transporter function has been maintained by selection across a range of different lifestyles. No evidence of neofunctionalization in terms of substrate specificity was detected for different HGT transporter paralogues which have different patterns of temporal expression. However, a striking expansion of substrate range was observed for one plant pathogenic oomycete, with a HGT derived paralogue from Pythium aphanidermatum encoding a protein that enables tricarboxylic acid uptake in addition to dicarboxylic acid uptake. This demonstrates that HGT acquisitions can provide functional additions to the recipient proteome as well as the foundation material for the evolution of expanded protein functions.
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