Evidence map›Paper›PMID 29701642›Full record

ArticleViruses2018

Characterization of

Ruben Brandão, Rute Marcelino, Fátima Gonçalves, Isabel Diogo, Ana Carvalho, Joaquim Cabanas, Inês Costa, Pedro Brogueira, Fernando Ventura, Ana Miranda and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ruben BrandãoMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. ruben8brandao@gmail.com.ORCID 0000-0002-5173-953X
Rute MarcelinoGlobal Health and Tropical Medicine (GHTM), Unit of Medical Microbiology, Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), 1349-008 Lisboa, Portugal. rute.marcelino@ihmt.unl.pt.ORCID 0000-0002-4535-9725
Fátima GonçalvesMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. mfmgoncalves@chlo.min-saude.pt.
Isabel DiogoMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. ifmadeira@chlo.min-saude.pt.
Ana CarvalhoMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. pkarvalho@iol.pt.
Joaquim CabanasMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. jcabanas65@gmail.com.
Inês CostaMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. icosta@chlo.min-saude.pt.
Pedro BrogueiraServiço de Doenças Infeciosas, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. pbrogueira@gmail.com.
Fernando VenturaServiço de Doenças Infeciosas, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. venturafa@gmail.com.
Ana MirandaServiço de Doenças Infeciosas, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. anacbcm@gmail.com.
Kamal MansinhoServiço de Doenças Infeciosas, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. mansinho.k@gmail.com.
Perpétua GomesMolecular Biology Laboratory, LMCBM, SPC, HEM-Centro Hospitalar Lisboa Ocidental, 1349-019 Lisboa, Portugal. gomes.perpetua@gmail.com.ORCID 0000-0003-3271-8255
Centro Hospitalar de Lisboa Ocidental · PTEscola Superior de Saúde Egas Moniz · PTUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5 coding region, which is followed by Sanger population sequencing.

Indexed as

AdultAgedAged, 80 and overAmino Acid SubstitutionAntiviral AgentsBenzimidazolesCohort StudiesDrug Resistance, ViralFemaleFluorenesGenotypeHepacivirusHepatitis CHumansMaleMiddle AgedAntiviral AgentsBenzimidazolesFluorenesledipasvir, sofosbuvir drug combinationNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseRNA, ViralSofosbuvirUridine MonophosphateViral Nonstructural Proteinsdirect-acting antiviralshepatitis C virusNS5ANS5Bresistance-associated substitutions

Identifiers

PMID29701642
PMCPMC5977216
OpenAlexW2802383019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.