Evidence map›Paper›PMID 29701446›Full record

ArticleEnvironmental health perspectives2018

Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture.

Sharon K Sagiv, Maria H Harris, Robert B Gunier, Katherine R Kogut, Kim G Harley, Julianna Deardorff, Asa Bradman, Nina Holland, Brenda Eskenazi

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sharon K SagivCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Maria H HarrisCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Robert B GunierCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Katherine R KogutCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Kim G HarleyCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Julianna DeardorffCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Asa BradmanCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Nina HollandCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Center for Environmental Health · US

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Early Adversity Shapes Adolescent Risk Behavior Trajectories in Mexican Americans (Diversity Supplement)R01DA035300 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DEARDORFF, JULIANNA · 2014 to 2018
$3.1M
Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohortUG3OD023356 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2016 to 2017
$2.6M
PBDEs, DDT and Neurodevelopment in School-Aged Mexican-American ChildrenR01ES015572 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2007 to 2010
$2.0M
NIDA NIH HHS R01 DA035300NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES015572NIH HHS UG3 OD023356
6 · The paper itself

Abstract

backgroundPrenatal exposure to organophosphate (OP) pesticides has been linked with poorer neurodevelopment and behaviors related to autism spectrum disorders (ASD) in previous studies, including in the Center for Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort living in the agricultural Salinas Valley in California.

objectivesTo investigate the association of prenatal exposure to OP pesticides with traits related to ASD, in childhood and adolescents in CHAMACOS.

methodsWe assessed OP exposure during pregnancy with measurements of dialkyl phosphates (DAP) metabolites in urine, and residential proximity to OP use during pregnancy using California's Pesticide Use Reporting (PUR) data and estimated associations with ASD-related traits using linear regression models. We measured traits reported by parents and teachers as well as the child's performance on tests that evaluate the ability to use facial expressions to recognize the mental state of others at 7, 10

resultsPrenatal DAPs were associated with poorer parent and teacher reported social behavior [e.g., a 10-fold DAP increase was associated with a 2.7-point increase (95% confidence interval (CI): 0.9, 4.5) in parent-reported Social Responsiveness Scale, Version 2, T-scores at age 14]. We did not find clear evidence of associations between residential proximity to OP use during pregnancy and ASD-related traits.

conclusionsThese findings contribute mixed evidence linking OP pesticide exposures with traits related to developmental disorders like ASD. Subtle pesticide-related effects on ASD-related traits among a population with ubiquitous exposure could result in a rise in cases of clinically diagnosed disorders like ASD. https://doi.org/10.1289/EHP2580.

Indexed as

AdolescentAgricultureAutism Spectrum DisorderCaliforniaChildEnvironmental ExposureFemaleHumansLinear ModelsMaleOrganophosphatesPesticidesPregnancyPrenatal Exposure Delayed EffectsOrganophosphatesPesticides

Identifiers

PMID29701446
PMCPMC6071837
OpenAlexW2799703896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.