Evidence map›Paper›PMID 29701016›Full record

ArticleStem cells translational medicine2018

Functional Integrity and Gene Expression Profiles of Human Cord Blood-Derived Hematopoietic Stem and Progenitor Cells Generated In Vitro.

Roberto Dircio-Maldonado, Patricia Flores-Guzman, Julieta Corral-Navarro, Ileana Mondragón-García, Alfredo Hidalgo-Miranda, Fredy Omar Beltran-Anaya, Alberto Cedro-Tanda, Lourdes Arriaga-Pizano, Odette Balvanera-Ortiz, Hector Mayani

Abstract read
In one paragraph

Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Autologous cord blood in children with cerebral palsy: a review.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberto Dircio-MaldonadoHematopoietic Stem Cells Laboratory, Oncology Research Unit, Oncology Hospital.
Patricia Flores-GuzmanHematopoietic Stem Cells Laboratory, Oncology Research Unit, Oncology Hospital.
Julieta Corral-NavarroHematopoietic Stem Cells Laboratory, Oncology Research Unit, Oncology Hospital.
Ileana Mondragón-GarcíaHematopoietic Stem Cells Laboratory, Oncology Research Unit, Oncology Hospital.
Alfredo Hidalgo-MirandaNational Ministry of Health, National Institute of Genomic Medicine, Mexico City, Mexico.
Fredy Omar Beltran-AnayaNational Ministry of Health, National Institute of Genomic Medicine, Mexico City, Mexico.
Alberto Cedro-TandaNational Ministry of Health, National Institute of Genomic Medicine, Mexico City, Mexico.
Lourdes Arriaga-PizanoImmunochemistry Research Unit, Medical Specialties Hospital, IMSS National Medical Center, Mexico City, Mexico.
Odette Balvanera-OrtizTroncoso General Hospital, IMSS, Mexico City, Mexico.
Hector MayaniHematopoietic Stem Cells Laboratory, Oncology Research Unit, Oncology Hospital.ORCID 0000-0002-2483-3782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, different experimental strategies have been developed for the ex vivo expansion of human hematopoietic stem (HSCs) and progenitor (HPCs) cells. This has resulted in significant advances on the use of such expanded cells in transplantation settings. To this day, however, it is still unclear to what extent those stem and progenitor cells generated in vitro retain the functional and genomic integrity of their freshly isolated counterparts. In trying to contribute to the solving of this issue, in the present study we have selected and purified three different hematopoietic cell populations: HSCs (CD34

Indexed as

TranscriptomeAntigens, CDAntigens, CD34Cell Culture TechniquesCells, CulturedFetal BloodHematopoietic Stem CellsHumansLeukocyte Common AntigensOligonucleotide Array Sequence AnalysisReceptors, TransferrinStem CellsAntigens, CDAntigens, CD34CD71 antigenLeukocyte Common AntigensReceptors, TransferrinCord bloodEx vivo expansionGene expression profilesHematopoietic stem and progenitor cells

Identifiers

PMID29701016
PMCPMC6090508

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.