Evidence map›Paper›PMID 29700982›Full record

ArticleChembiochem : a European journal of chemical biology2018

FaptaSyme: A Strategy for Converting a Monomer/Oligomer-Nonselective Aptameric Sensor into an Oligomer-Selective One.

Baggio A Evangelista, Yoon-Seong Kim, Dmitry M Kolpashchikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Baggio A EvangelistaBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32816, USA.
Yoon-Seong KimBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32816, USA.
Dmitry M KolpashchikovBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32816, USA.ORCID http://orcid.org/0000-0002-8682-6553

Funding

Deoxyribozyme sensor-based diagnostics for Mycobacterium tuberculosisR15AI103880 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI KOLPASHCHIKOV, DMITRY MIKHAYLOVICH · 2013 to 2013
$430k
NIAID NIH HHS R15 AI103880
6 · The paper itself

Abstract

Aptameric sensors can bind molecular targets and produce output signals, a phenomenon that is used in bioassays. In some cases, it is important to distinguish between monomeric and oligomeric forms of a target. Here, we propose a strategy to convert a monomer/oligomer-nonselective sensor into an oligomer-selective sensor. We designed an aptazyme that produced a high fluorescent output in the presence of oligomeric α-synuclein (a molecular marker of Parkinson's disease) but not its monomeric form. The strategy is potentially useful in the design of point-of-care tests for the diagnosis of neurodegenerative diseases.

Indexed as

aptamersaptazymesbiosensorsdeoxyribozymessplit probes

Identifiers

PMID29700982
PMCPMC6422747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.