ArticleHuman brain mapping2018
Action and semantic tool knowledge - Effective connectivity in the underlying neural networks.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Limb apraxia and active inference in the visuomotor pathways.Psychonomic bulletin & review · 2026Review
- Manipulable object processing reveals distinct neural and behavioral signatures for visual, functional, and manipulation properties.Communications psychology · 2026Article
- Neurocognitive mechanisms underlying action tool knowledge tasks: specificity of tool-tool compared to hand-tool compatibility tasks.Communications biology · 2025Article
- Neural and behavioral similarity-driven tuning curves for manipulable objects.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional and Effective Connectivity Underlying Semantic Verbal Fluency.Brain topography · 2024Article
- Neural and behavioral signatures of the multidimensionality of manipulable object processing.Communications biology · 2023Article
- Tool mastering today - an interdisciplinary perspective.Frontiers in psychology · 2023Review
- Hand constraint reduces brain activity and affects the speed of verbal responses on semantic tasks.Scientific reports · 2022Article
- Effective connectivity underlying reward-based executive control.Human brain mapping · 2021Article
- Neural encoding and functional interactions underlying pantomimed movements.Brain structure & function · 2021Article
- Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity.Cerebral cortex communications · 2020Article
- Gesturing tool use and tool transport actions modulates inferior parietal functional connectivity with the dorsal and ventral object processing pathways.Human brain mapping · 2019Article
- Neural correlates of differential finger gesture imitation deficits in left hemisphere stroke.NeuroImage. Clinical · 2019Article
- Action and semantic tool knowledge - Effective connectivity in the underlying neural networks.Human brain mapping · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
Evidence from neuropsychological and imaging studies indicate that action and semantic knowledge about tools draw upon distinct neural substrates, but little is known about the underlying interregional effective connectivity. With fMRI and dynamic causal modeling (DCM) we investigated effective connectivity in the left-hemisphere (LH) while subjects performed (i) a function knowledge and (ii) a value knowledge task, both addressing semantic tool knowledge, and (iii) a manipulation (action) knowledge task. Overall, the results indicate crosstalk between action nodes and semantic nodes. Interestingly, effective connectivity was weakened between semantic nodes and action nodes during the manipulation task. Furthermore, pronounced modulations of effective connectivity within the fronto-parietal action system of the LH (comprising lateral occipito-temporal cortex, intraparietal sulcus, supramarginal gyrus, inferior frontal gyrus) were observed in a bidirectional manner during the processing of action knowledge. In contrast, the function and value knowledge tasks resulted in a significant strengthening of the effective connectivity between visual cortex and fusiform gyrus. Importantly, this modulation was present in both semantic tasks, indicating that processing different aspects of semantic knowledge about tools evokes similar effective connectivity patterns. Data revealed that interregional effective connectivity during the processing of tool knowledge occurred in a bidirectional manner with a weakening of connectivity between areas engaged in action and semantic knowledge about tools during the processing of action knowledge. Moreover, different semantic tool knowledge tasks elicited similar effective connectivity patterns.
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