ReviewThe Journal of physiology2018
Therapeutic potential to reduce brain injury in growth restricted newborns.
Review in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Peripheral blood cell counts of prematurely born, small for gestational age neonates.Clinical and experimental pediatrics · 2026Article
- Article
- Early assessment and analysis of high-risk factors of neurodevelopmental impairment in neonates with congenital diaphragmatic hernia.Frontiers in pediatrics · 2025Article
- Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia.Neonatology · 2024Article
- Does fetal growth restriction induce neuropathology within the developing brainstem?The Journal of physiology · 2023Review
- Acupuncture on intrauterine growth restriction associated brain injury: case study including use of magnetic resonance imaging.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress.Frontiers in endocrinology · 2023Review
- Blood-Brain Barrier Disintegration in Growth-Restricted Fetuses with Brain Sparing Effect.International journal of molecular sciences · 2022Article
- Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn.NPJ Regenerative medicine · 2021Article
- Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction.Brain pathology (Zurich, Switzerland) · 2021Article
- Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion.Neurochemical research · 2020Article
- Fetal Growth Restriction Alters Cerebellar Development in Fetal and Neonatal Sheep.Frontiers in physiology · 2019Article
- Ibuprofen Treatment Reduces the Neuroinflammatory Response and Associated Neuronal and White Matter Impairment in the Growth Restricted Newborn.Frontiers in physiology · 2019Article
- Challenges and controversies in perinatal physiology.The Journal of physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brain injury in intrauterine growth restricted (IUGR) infants is a major contributing factor to morbidity and mortality worldwide. Adverse outcomes range from mild learning difficulties, to attention difficulties, neurobehavioral issues, cerebral palsy, epilepsy, and other cognitive and psychiatric disorders. While the use of medication to ameliorate neurological deficits in IUGR neonates has been identified as warranting urgent research for several years, few trials have been reported. This review summarises clinical trials focusing on brain protection in the IUGR newborn as well as therapeutic interventions trialled in animal models of IUGR. Therapeutically targeting mechanisms of brain injury in the IUGR neonate is fundamental to improving long-term neurodevelopmental outcomes. Inflammation is a key mechanism in neonatal brain injury; and therefore an appealing target. Ibuprofen, an anti-inflammatory drug currently used in the preterm neonate, may be a potential therapeutic candidate to treat brain injury in the IUGR neonate. To better understand the potential of ibuprofen and other therapeutic agents to be neuroprotective in the IUGR neonate, long-term follow-up information of neurodevelopmental outcomes must be studied. Where agents such as ibuprofen are shown to be effective, have a good safety profile and are relatively inexpensive, they can be widely adopted and lead to improved outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.