Evidence map›Paper›PMID 29700825›Full record

ArticleBiopolymers2018

Synthetic polymers as substrates for a DNA-sliding clamp protein.

S F M van Dongen, J Clerx, O I van den Boomen, M Pervaiz, M A Trakselis, T Ritschel, L Schoonen, D C Schoenmakers, R J M Nolte

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biopolymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

S F M van DongenRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.
J ClerxRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.
O I van den BoomenRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.
M PervaizCenter for Molecular and Biomolecular Informatics (CMBI). Radboud University Medical Center, Geert Grooteplein Zuid 26-28, Nijmegen, HB, 6500, The Netherlands.
M A TrakselisBaylor University, Department of Chemistry and Biochemistry, One Bear Place #97348, Waco, Texas, 76798-7348.
T RitschelCenter for Molecular and Biomolecular Informatics (CMBI). Radboud University Medical Center, Geert Grooteplein Zuid 26-28, Nijmegen, HB, 6500, The Netherlands.
L SchoonenRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.
D C SchoenmakersRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.
R J M NolteRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, 6525, AJ, The Netherlands.ORCID http://orcid.org/0000-0002-5612-7815
Radboud University Nijmegen · NLBaylor University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clamp protein (gp45) of the DNA polymerase III of the bacteriophage T4 is known to bind to DNA and stay attached to it in order to facilitate the process of DNA copying by the polymerase. As part of a project aimed at developing new biomimetic data-encoding systems we have investigated the binding of gp45 to synthetic polymers, that is, rigid, helical polyisocyanopeptides. Molecular modelling studies suggest that the clamp protein may interact with the latter polymers. Experiments aimed at verifying these interactions are presented and discussed.

Indexed as

Bacteriophage T4Binding SitesDNADNA Polymerase IIIKineticsMolecular Dynamics SimulationPeptidomimeticsProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsSubstrate SpecificityThermodynamicsViral ProteinsDNADNA Polymerase IIIPeptidomimeticsViral Proteins

Identifiers

PMID29700825
PMCPMC6001473
OpenAlexW2802817261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.