Evidence map›Paper›PMID 29700718›Full record

ReviewCurrent obesity reports2018

Intermittent Fasting: Is the Wait Worth the Weight?

Mary-Catherine Stockman, Dylan Thomas, Jacquelyn Burke, Caroline M Apovian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current obesity reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mary-Catherine StockmanSection of Endocrinology, Diabetes and Nutrition, Boston Medical Center, 720 Harrison Avenue, 8th Floor, Boston, MA, 02118, USA. Mary-Catherine.Stockman@bmc.org.
Dylan ThomasSection of Endocrinology, Diabetes and Nutrition, Boston Medical Center, 720 Harrison Avenue, 8th Floor, Boston, MA, 02118, USA.
Jacquelyn BurkeCollege of Health and Rehabilitation Sciences, Boston University Sargent College, 635 Commonwealth Avenue, Boston, MA, 02215, USA.
Caroline M ApovianSection of Endocrinology, Diabetes and Nutrition, Boston Medical Center, 720 Harrison Avenue, 8th Floor, Boston, MA, 02118, USA.

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
TRAINING PROGRAM IN ENDOCRINE AND METABOLIC RESEARCHT32DK007201 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CORKEY, BARBARA E., KANDROR, KONSTANTIN V · 1986 to 2023
$6.4M
National Institutes of Health P30DK046200National Institutes of Health T32DK007201National Institutes of Health UL1TR001430NCATS NIH HHS UL1 TR001430NIDDK NIH HHS P30 DK046200NIDDK NIH HHS T32 DK007201
6 · The paper itself

Abstract

purpose of reviewWe review the underlying mechanisms and potential benefits of intermittent fasting (IF) from animal models and recent clinical trials. RECENT

findingsNumerous variations of IF exist, and study protocols vary greatly in their interpretations of this weight loss trend. Most human IF studies result in minimal weight loss and marginal improvements in metabolic biomarkers, though outcomes vary. Some animal models have found that IF reduces oxidative stress, improves cognition, and delays aging. Additionally, IF has anti-inflammatory effects, promotes autophagy, and benefits the gut microbiome. The benefit-to-harm ratio varies by model, IF protocol, age at initiation, and duration. We provide an integrated perspective on potential benefits of IF as well as key areas for future investigation. In clinical trials, caloric restriction and IF result in similar degrees of weight loss and improvement in insulin sensitivity. Although these data suggest that IF may be a promising weight loss method, IF trials have been of moderate sample size and limited duration. More rigorous research is needed.

Indexed as

AnimalsCaloric RestrictionCircadian RhythmDiet FadsDiet, ReducingDysbiosisFastingHumansImmunomodulationInsulin ResistanceObesityOverweightOxidative StressWeight LossCalorie restrictionFastingInsulin resistanceIntermittent fastingMetabolismObesityWeight loss

Identifiers

PMID29700718
PMCPMC5959807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.