ArticleJournal of molecular modeling2018
Molecular insights into the antifungal mechanism of bacilysin.
Article in Journal of molecular modeling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
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- Bacillus velezensis Bac-9, isolated from kefir, possesses antifungal activity and improves resistance of tomato plant against whitefly Bemisia tabaci.BMC microbiology · 2025Article
- The Influence of Bacterial Inoculants and a Biofertilizer on Maize Cultivation and the Associated Shift in Bacteriobiota During the Growing Season.Plants (Basel, Switzerland) · 2025Article
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- Whole genome sequencing provides evidence for Bacillus velezensis SH-1471 as a beneficial rhizosphere bacterium in plants.Scientific reports · 2023Article
- Detection of Antagonistic Compounds Synthesized byMicroorganisms · 2023Article
- Functional Analyses of theCells · 2023Article
- Improvement of Bacilysin Production inJournal of microbiology and biotechnology · 2023Article
- Genomic insights into antimicrobial potential and optimization of fermentation conditions of pig-derivedFrontiers in microbiology · 2023Article
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- Genomic and Metabolomic Insights into Secondary Metabolites of the NovelMicroorganisms · 2021Article
- Genomic Analysis and Secondary Metabolites Production of the EndophyticPlants (Basel, Switzerland) · 2021Article
- Endophytic BacteriaBiology · 2021Article
- Peeling the Layers Away: The Genomic Characterization ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bacilysin is one of the simplest antimicrobial peptides and has drawn great attention for its excellent performance against Candida albicans. In this study, the antifungal mechanism of bacilysin was investigated. The target enzyme glucosamine-6-phosphate synthase (GFA) was expressed heterologously in Escherichia coli and its inhibition by bacilysin and derivatives was studied. It was concluded that bacilysin could be hydrolyzed by a proteinase of C. albicans, and that the released product, anticapsin, then inhibited the aminotransferase activity of GFA. This result was verified by molecular simulation, and the interaction mode of anticapsin with GFA was detailed, which provides data for the development of novel antifungal drugs. Transport of bacilysin into fungal cells was also simulated and it was shown that bacilysin is more readily transported into cells than anticapsin. Thus, our findings support a mechanism whereby bacilysin is transported into fungal pathogens, hydrolyzed to anticapsin, which then inhibits GFA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.