Evidence map›Paper›PMID 29700425›Full record

ArticleThe Journal of antibiotics2018

Isolation of a jadomycin incorporating L-ornithine, analysis of antimicrobial activity and jadomycin reactive oxygen species (ROS) generation in MDA-MB-231 breast cancer cells.

Stephanie M Forget, Andrew W Robertson, Steven R Hall, Jeanna M MacLeod, David P Overy, Russell G Kerr, Kerry B Goralski, David L Jakeman

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stephanie M ForgetDepartment of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Andrew W RobertsonDepartment of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Steven R HallCollege of Pharmacy, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Jeanna M MacLeodCollege of Pharmacy, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
David P OveryDepartment of Chemistry, University of Prince Edward Island, Charlottetown, PE, C1A 4P3, Canada.
Russell G KerrDepartment of Chemistry, University of Prince Edward Island, Charlottetown, PE, C1A 4P3, Canada.
Kerry B GoralskiCollege of Pharmacy, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
David L JakemanDepartment of Chemistry, Dalhousie University, Halifax, NS, B3H 4R2, Canada. david.jakeman@dal.ca.
Dalhousie University · CAUniversity of Prince Edward Island · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report the characterization and antimicrobial activity of a previously unreported jadomycin (1) obtained from a culture of S. venezuelae ISP5230 with L-ornithine (Orn). 1 arises from the rearrangement of a putative five-membered ring containing jadomycin incorporating Orn, whereby intramolecular attack of the E-ring carbonyl from the δ-NH

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCell Line, TumorCell SurvivalDrug Resistance, NeoplasmHumansIsoquinolinesMicrobial Sensitivity TestsOrnithineReactive Oxygen SpeciesStaphylococcusStreptomycesStructure-Activity RelationshipTriple Negative Breast NeoplasmsAnti-Bacterial AgentsAntineoplastic AgentsIsoquinolinesOrnithineReactive Oxygen Species

Identifiers

PMID29700425
OpenAlexW2802285859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.