Evidence map›Paper›PMID 29700388›Full record

ArticleProstate cancer and prostatic diseases2018

Changes in cerebral metabolic activity in men undergoing androgen deprivation therapy for non-metastatic prostate cancer.

M M Cherrier, D J Cross, C S Higano, S Minoshima

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Effect of androgen deprivation therapy on cognitive functioning in men with prostate cancer: A systematic review.International journal of urology : official journal of the Japanese Urological Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M M CherrierDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. cherrier@u.washington.edu.
D J CrossDepartment of Radiology and Imaging Sciences, University of Utah, School of Medicine, Salt Lake City, UT, USA.
C S HiganoDepartment of Medicine, Division of Oncology and Urology, University of Washington School of Medicine, Seattle, WA, USA.
S MinoshimaDepartment of Radiology and Imaging Sciences, University of Utah, School of Medicine, Salt Lake City, UT, USA.
University of Utah · USUniversity of Washington · US

Funding

ZIPRASIDONE IN NORMAL HEPATIC FUNCTION SUBJECTS &IN HEPATIC DYSFUCTIN SUBJECTSM01RR000037 · NCRR · UNIVERSITY OF WASHINGTON · PI MCDONALD, RUTH C · 1985 to 2007
$33.8M
Assessment of Cognitive & Mood Effects from ADT in Men with Prostate CancerR01CA120933 · NCI · UNIVERSITY OF WASHINGTON · PI CHERRIER, MONIQUE · 2007 to 2011
$1.1M
TESTOSTERONE EFFECTS ON SPATIAL MEMORY IN AGING AND ADK01AG000858 · NIA · UNIVERSITY OF WASHINGTON · PI CHERRIER, MONIQUE · 1999 to 2003
$446k
NCI NIH HHS R01 CA120933NCRR NIH HHS M01 RR000037NIA NIH HHS K01 AG000858
6 · The paper itself

Abstract

objectiveAndrogen deprivation therapy (ADT) is a common treatment option for men with biochemical relapse from prostate cancer. ADT is associated with changes in mood, cognition, and quality of life, and most recently with increased risk for Alzheimer's disease (AD). This study examined changes in brain metabolism using positron emission tomography (PET) in men undergoing intermittent ADT.

methodsNine men with prostate cancer and a rising PSA (biochemical recurrence) without evidence of metastases were treated with intermittent ADT consisting of 9 months of complete androgen blockade achieved with combined leuprolide acetate and flutamide. Patients underwent resting [Fuorine-18] fluorodeoxyglucose PET (

resultsWhole-brain mapping analysis after 9 months of androgen deprivation compared to pretreatment baseline revealed decreased regional cerebral glucose metabolism in the cerebellum, posterior cingulate, and medial thalamus bilaterally. Associations of brain metabolism with measurements of cognition and mood while on androgen deprivation revealed positive correlations between the posterior cingulate, left inferior parietal lobule (BA40), and left mid temporal gyrus (BA39) and spatial reasoning and a negative correlation between left inferior parietal lobule and verbal memory. Several mood indices were negatively correlated with hypothalamus and brainstem.

conclusionThese findings suggest that complete androgen deprivation may result in changes in regional brain metabolism associated with variation in mood, verbal memory, and spatial performance. Brain regions that were impacted from ADT are similar and overlap with brain regions with metabolic decline found in early AD and diabetes, suggesting possible common mechanisms.

Indexed as

Quality of LifeAffectAgedAndrogen AntagonistsAntineoplastic Combined Chemotherapy ProtocolsBrainCognitionFlutamideHumansKallikreinsLeuprolideMaleMiddle AgedPositron-Emission TomographyProstate-Specific AntigenProstatic NeoplasmsAndrogen AntagonistsFlutamideKallikreinsKLK3 protein, humanLeuprolideProstate-Specific Antigen

Identifiers

PMID29700388
PMCPMC6125255
OpenAlexW2802685531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.