Evidence map›Paper›PMID 29700330›Full record

ArticleScientific reports2018

Prion protein modulates glucose homeostasis by altering intracellular iron.

Ajay Ashok, Neena Singh

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
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  5. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Review
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  12. Article
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Prions and prion diseases: Insights from the eye.Experimental eye research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ajay AshokDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Neena SinghDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA. neena.singh@case.edu.
Case Western Reserve University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
The iron modulatory function of prion protein and prion disordersR01NS092145 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2015 to 2019
$2.4M
Local hepcidin in the anterior segment: Physiological and pathological implicationsR21EY032694 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2022 to 2023
$443k
NEI NIH HHS P30 EY011373NEI NIH HHS R21 EY032694NINDS NIH HHS R01 NS092145
6 · The paper itself

Abstract

The prion protein (PrP

Indexed as

HomeostasisAnimalsBiological TransportBlood GlucoseCarbohydrate MetabolismFluorescent Antibody TechniqueGene ExpressionGlucoseInsulinomaIntracellular SpaceIronLiverMiceMice, KnockoutModels, BiologicalPancreasBlood GlucoseGlucoseIronPrion ProteinsPrPC Proteins

Identifiers

PMID29700330
PMCPMC5919926
OpenAlexW2805660344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.