ReviewPediatrics2018
Antibiotic Allergy in Pediatrics.
Review in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 123 citations in OpenAlex.
- Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement.The World Allergy Organization journal · 2026Review
- Patch Testing in Paediatric Drug Hypersensitivity Reactions: Current Evidence and Clinical Implications.Contact dermatitis · 2026Review
- Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record.British journal of clinical pharmacology · 2026Article
- The Feasibility and Applicability of Pediatric Inpatient Beta Lactam De-Labeling: From Bedside Challenge to Long-Term Follow Up.Infection & chemotherapy · 2026Article
- Article
- Direct single dose mass delabelling of antibiotic allergy in pediatrics.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Updates in Pediatric Drug Allergy.Current allergy and asthma reports · 2026Review
- Once Allergic, Now Not: Do Children Use Delabeled Antibiotics?-A 5-Year Follow-Up Study.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- De-Labelling Penicillin Allergies in the Paediatric Emergency Department.Antibiotics (Basel, Switzerland) · 2025Review
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.The World Allergy Organization journal · 2025Review
- Nurse-Initiated Improvement for Documentation of Penicillin Adverse Drug Reactions in Pediatric Urgent Care Clinics.Children (Basel, Switzerland) · 2025Article
- PEN-FAST in pediatrics: a reliable tool for penicillin allergy assessment?European journal of pediatrics · 2025Article
- Success of amoxicillin challenges in the emergency department for children with low risk of serious reactions.Paediatrics & child health · 2025Article
- Outcomes of antibiotic treatment for respiratory infections in children an observational study in primary care.Scandinavian journal of primary health care · 2024Observational
- Recent findings on drug hypersensitivity in children.Frontiers in allergy · 2024Review
- A 14-year-old boy with severe erythema multiforme due to amoxicillin.Asia Pacific allergy · 2023Article
- Article
- Impact of Penicillin Allergy Labels on Children Treated for Outpatient Respiratory Infections.Journal of the Pediatric Infectious Diseases Society · 2023Article
- The state and consideration for skin test of β-lactam antibiotics in pediatrics.Frontiers in cellular and infection microbiology · 2023Review
- The epidemiology of cephalosporin allergy labels in pediatric primary care.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The overlabeling of pediatric antibiotic allergy represents a huge burden in society. Given that up to 10% of the US population is labeled as penicillin allergic, it can be estimated that at least 5 million children in this country are labeled with penicillin allergy. We now understand that most of the cutaneous symptoms that are interpreted as drug allergy are likely viral induced or due to a drug-virus interaction, and they usually do not represent a long-lasting, drug-specific, adaptive immune response to the antibiotic that a child received. Because most antibiotic allergy labels acquired in childhood are carried into adulthood, the overlabeling of antibiotic allergy is a liability that leads to unnecessary long-term health care risks, costs, and antibiotic resistance. Fortunately, awareness of this growing burden is increasing and leading to more emphasis on antibiotic allergy delabeling strategies in the adult population. There is growing literature that is used to support the safe and efficacious use of tools such as skin testing and drug challenge to evaluate and manage children with antibiotic allergy labels. In addition, there is an increasing understanding of antibiotic reactivity within classes and side-chain reactions. In summary, a better overall understanding of the current tools available for the diagnosis and management of adverse drug reactions is likely to change how pediatric primary care providers evaluate and treat patients with such diagnoses and prevent the unnecessary avoidance of antibiotics, particularly penicillins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.