Evidence map›Paper›PMID 29700126›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Imaging Melphalan Therapy Response in Preclinical Extramedullary Multiple Myeloma with

Deep K Hathi, Elizabeth N DeLassus, Samuel Achilefu, Jonathan McConathy, Monica Shokeen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Comparison between tumour metabolism derived fromQuantitative imaging in medicine and surgery · 2021
    Article
  2. VLA4-Targeted Nanoparticles Hijack Cell Adhesion-Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Deep K HathiDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
Elizabeth N DeLassusDepartment of Biochemistry and Biophysics, Washington University in St. Louis, St. Louis, Missouri; and.
Samuel AchilefuDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.
Jonathan McConathyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Monica ShokeenDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri mshokeen@wustl.edu.
Washington University in St. Louis · USUniversity of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
RECEPTOR TARGETED MOLECULAR IMAGING OF MULTIPLE MYELOMAR01CA176221 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2013 to 2015
$946k
NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA171651NCI NIH HHS R01 CA176221NCI NIH HHS U54 CA199092NIBIB NIH HHS R01 EB021048
6 · The paper itself

Abstract

Multiple myeloma (MM) is a debilitating neoplasm of terminally differentiated plasma B cells that resulted in over 13,000 deaths in 2017 alone. Combination therapies involving melphalan, a small-molecule DNA alkylating agent, are commonly prescribed to patients with relapsed or refractory MM, necessitating the stratification of responding patients to minimize toxicities and improve quality of life. Here, we evaluated the use of 3,4-dihydroxy-6-

Indexed as

Fluorodeoxyglucose F18Positron-Emission TomographyAnimalsCell Line, TumorCell Transformation, NeoplasticDihydroxyphenylalanineHumansMelphalanMiceMultiple MyelomaTreatment OutcomeTumor BurdenDihydroxyphenylalanineFluorodeoxyglucose F18fluorodopa F 18Melphalan18F-FDG PET18F-FDOPA PETmelphalan therapy responsemultiple myeloma

Identifiers

PMID29700126
PMCPMC6167538
OpenAlexW2800222841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.