Evidence map›Paper›PMID 29700113›Full record

ArticleThe Journal of biological chemistry2018

Autophagy regulates exosomal release of prions in neuronal cells.

Basant A Abdulrahman, Dalia H Abdelaziz, Hermann M Schatzl

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. A Neuronal Cell Line Model for Studying Camel Prions.Pathogens (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Enhanced lysosomal activity prevents infection with PrPThe Journal of biological chemistry · 2026
    Article
  6. Article
  7. Extracellular vesicles inEXO : beyond the cell · 2026
    Article
  8. Autophagy activation by the Becn1Brain, behavior, and immunity · 2026
    Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. The multiple functions of PrPJournal of molecular medicine (Berlin, Germany) · 2022
    Review
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 3 countries.

Basant A AbdulrahmanFrom the Department of Comparative Biology & Experimental Medicine and.
Dalia H AbdelazizFrom the Department of Comparative Biology & Experimental Medicine and.
Hermann M SchatzlFrom the Department of Comparative Biology & Experimental Medicine and hschaetz@ucalgary.ca.
University of Calgary · CA

Funding

Elucidating the cellular mechanisms of prion propagation and clearance for devisiR01NS076853 · NINDS · UNIVERSITY OF WYOMING · PI JARVIS, DONALD L. · 2012 to 2016
$1.5M
NINDS NIH HHS R01 NS076853
6 · The paper itself

Abstract

Prions are protein-based infectious agents that autocatalytically convert the cellular prion protein PrP

Indexed as

AutophagyAnimalsCell LineExosomesMiceMice, Inbred C57BLNeurodegenerative DiseasesNeuronsPrion ProteinsPrion ProteinsautophagyCreutzfeldt–Jakob diseaseCRISPR/Casexosome (vesicle)extracellular vesiclesneurodegenerationprionprion diseaseRT-QuICscrapie

Identifiers

PMID29700113
PMCPMC5995502
OpenAlexW2802507063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.