Evidence map›Paper›PMID 29700052›Full record

ArticleSexually transmitted infections2018

Changes in recreational drug use, drug use associated with chemsex, and HIV-related behaviours, among HIV-negative men who have sex with men in London and Brighton, 2013-2016.

Janey Sewell, Valentina Cambiano, Ada Miltz, Andrew Speakman, Fiona C Lampe, Andrew Phillips, David Stuart, Richard Gilson, David Asboe, Nneka Nwokolo and 3 more

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Sexually transmitted infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Janey SewellResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.ORCID 0000-0001-7148-2391
Valentina CambianoResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
Ada MiltzResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
Andrew SpeakmanResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
Fiona C LampeResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
Andrew PhillipsResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
David StuartChelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Richard GilsonResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
David AsboeChelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Nneka NwokoloChelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Amanda ClarkeBrighton and Sussex University Hospitals NHS Trust, Brighton, UK.
Graham HartResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
Alison RodgerResearch Department of Infection and Population Health, Institute for Global Health, UCL, London, UK.
Biology of Infection · FRChelsea and Westminster Hospital NHS Foundation Trust · GBUniversity Hospitals Sussex NHS Foundation Trust · GB

Funding

Department of Health RP-PG-1212-20006
6 · The paper itself

Abstract

objectivesThe objective of this study was to compare the prevalence of polydrug use, use of drugs associated with chemsex, specific drug use, and HIV-related behaviours, between two time periods, using two groups of HIV-negative men who have sex with men (MSM) attending the same sexual health clinics in London and Brighton, in two consecutive periods of time from 2013 to 2016.

methodsData from MSM in the cross-sectional Attitudes to and Understanding Risk of Acquisition of HIV (AURAH) study (June 2013 to September 2014) were compared with baseline data from different MSM in the prospective cohort study Attitudes to and Understanding Risk of Acquisition of HIV over Time (AURAH2) (November 2014 to April 2016). Prevalence of polydrug use, drug use associated with chemsex and specific drug use, and 10 measures of HIV-related behaviours including condomless sex, post-exposure prophylaxis (PEP) use, pre-exposure prophylaxis (PrEP) use, and HIV testing, were compared. Prevalence ratios (PRs) for the association of the study (time period) with drug use and HIV-related behaviour measures were estimated using modified Poisson regression analysis, unadjusted and adjusted for sociodemographic factors.

resultsIn total, 991 MSM were included from AURAH and 1031 MSM from AURAH2. After adjustment for sociodemographic factors, use of drugs associated with chemsex had increased (adjusted PR (aPR) 1.30, 95% CI 1.11 to 1.53) and there were prominent increases in specific drug use; in particular, mephedrone (aPR 1.32, 95% CI 1.10 to 1.57), γ-hydroxybutyric/γ-butryolactone (aPR 1.47, 95% CI 1.15 to 1.87) and methamphetamine (aPR 1.42, 95% CI 1.01 to 2.01). Use of ketamine had decreased (aPR 0.54, 95% CI 0.38 to 0.78). Certain measures of HIV-related behaviours had also increased, most notably PEP use (aPR 1.50, 95% CI 1.21 to 1.88) and number of self-reported bacterial STI diagnoses (aPR 1.24, 95% CI 1.08 to 1.43).

conclusionsThere have been significant increases in drug use associated with chemsex and some measures of HIV-related behaviours among HIV-negative MSM in the last few years. Changing patterns of drug use and associated behaviours should be monitored to enable sexual health services to plan for the increasingly complex needs of some clients.

Indexed as

Health Knowledge, Attitudes, PracticeAdultCross-Sectional StudiesDrug UsersHIVHIV InfectionsHomosexuality, MaleHumansIllicit DrugsLondonMaleMethamphetamineMiddle AgedPre-Exposure ProphylaxisPrevalenceProspective StudiesIllicit DrugsmephedroneMethamphetaminechemsexcondomless sexHIV negativeHIV prevention.men who have sex with menpoly drug useRecreational drug usesexual behavioursexual health

Identifiers

PMID29700052
PMCPMC6227813
OpenAlexW2800817212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.