ArticleAJNR. American journal of neuroradiology2018
Segmentation of the Globus Pallidus Internus Using Probabilistic Diffusion Tractography for Deep Brain Stimulation Targeting in Parkinson Disease.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Measuring Subthalamic Nucleus Volume of Parkinson's Patients and Evaluating Its Relationship with Clinical Scales at Pre- and Postdeep Brain Stimulation Treatment: A Magnetic Resonance Imaging Study.BioMed research international · 2021Trial
- Probabilistic mapping of the antiparkinsonian effects of pallidal deep brain stimulation.Brain communications · 2025Article
- Virtual anatomical atlas of the deep brain nuclei.Neurosurgical review · 2024Article
- Deep brain stimulation in a pediatric dystonia patient with cochlear implants and mitochondrial disorder: novel application of a frameless stereotactic system and navigating the anesthesia choice and neurosurgical complexities. Illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Modality preserving U-Net for segmentation of multimodal medical images.Quantitative imaging in medicine and surgery · 2023Article
- Recent advances in using diffusion tensor imaging to study white matter alterations in Parkinson's disease: A mini review.Frontiers in aging neuroscience · 2022Review
- Globus Pallidus Internus (GPi) Deep Brain Stimulation for Parkinson's Disease: Expert Review and Commentary.Neurology and therapy · 2021Article
- Spatially coherent and topographically organized pathways of the human globus pallidus.Human brain mapping · 2020Article
- Opportunities of connectomic neuromodulation.NeuroImage · 2020Review
- Anatomical Characterization of the Human Structural Connectivity between the Pedunculopontine Nucleus and Globus Pallidus via Multi-Shell Multi-Tissue Tractography.Medicina (Kaunas, Lithuania) · 2020Article
- Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics.AJNR. American journal of neuroradiology · 2020Review
- A Comprehensive Review of Brain Connectomics and Imaging to Improve Deep Brain Stimulation Outcomes.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Functional and Structural Connectivity Patterns Associated with Clinical Outcomes in Deep Brain Stimulation of the Globus Pallidus Internus for Generalized Dystonia.AJNR. American journal of neuroradiology · 2020Article
- Evaluation of methodologies for computing the deep brain stimulation volume of tissue activated.Journal of neural engineering · 2019Article
- Article
- The Cortico-Basal Ganglia-Cerebellar Network: Past, Present and Future Perspectives.Frontiers in systems neuroscience · 2019Article
- Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Structural connectivity-based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus.NeuroImage. Clinical · 2018Article
- Time for a New 3-D Image for Globus Pallidus Internus Deep Brain Stimulation Targeting and Programming.Journal of Parkinson's diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
background and purposeAlthough globus pallidus internus deep brain stimulation is a widely accepted treatment for Parkinson disease, there is persistent variability in outcomes that is not yet fully understood. In this pilot study, we aimed to investigate the potential role of globus pallidus internus segmentation using probabilistic tractography as a supplement to traditional targeting methods. MATERIALS AND
methodsEleven patients undergoing globus pallidus internus deep brain stimulation were included in this retrospective analysis. Using multidirection diffusion-weighted MR imaging, we performed probabilistic tractography at all individual globus pallidus internus voxels. Each globus pallidus internus voxel was then assigned to the 1 ROI with the greatest number of propagated paths. On the basis of deep brain stimulation programming settings, the volume of tissue activated was generated for each patient using a finite element method solution. For each patient, the volume of tissue activated within each of the 10 segmented globus pallidus internus regions was calculated and examined for association with a change in the Unified Parkinson Disease Rating Scale, Part III score before and after treatment.
resultsIncreasing volume of tissue activated was most strongly correlated with a change in the Unified Parkinson Disease Rating Scale, Part III score for the primary motor region (Spearman
conclusionsIn this pilot study, we assessed a novel method of segmentation of the globus pallidus internus based on probabilistic tractography as a supplement to traditional targeting methods. Our results suggest that our method may be an independent predictor of deep brain stimulation outcome, and evaluation of a larger cohort or prospective study is warranted to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.