Evidence map›Paper›PMID 29699928›Full record

ArticleMolecular metabolism2018

Female sex hormones are necessary for the metabolic effects mediated by loss of Interleukin 18 signaling.

Birgitte Lindegaard, Julie Abildgaard, Sarah E Heywood, Bente K Pedersen, Mark A Febbraio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Sex Differences in Inflammation and Muscle Wasting in Aging and Disease.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Birgitte LindegaardCentre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Denmark; Department of Pulmonary and Infectious Diseases, Nordsjællands Hospital, Hillerød, Denmark. Electronic address: birgitte.lindegaard.madsen@regionh.dk.
Julie AbildgaardCentre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Denmark.
Sarah E HeywoodCentre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Denmark; Cellular and Molecular Metabolism Laboratory, Division of Diabetes & Metabolism, Garvan Institute for Medical Research, Sydney, Australia.
Bente K PedersenCentre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Denmark.
Mark A FebbraioCellular and Molecular Metabolism Laboratory, Division of Diabetes & Metabolism, Garvan Institute for Medical Research, Sydney, Australia. Electronic address: m.febbraio@garvan.org.au.
University of Copenhagen · DKGarvan Institute of Medical Research · AURigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInterleukin (IL)-18 plays a crucial role in maintaining metabolic homeostasis and levels of this cytokine are influenced by gender, age, and sex hormones. The role of gender on IL-18 signaling, however, is unclear. We hypothesized that the presence of female sex hormone could preserve the metabolic phenotype of the IL-18R

methodsWe studied female mice with a global deletion of the α isoform of the IL-18 receptor (IL-18R

resultsFemale IL-18R

conclusionsFemale mice harboring a global deletion of the IL-18R, only present the same phenotype as reported in male IL-18R

Indexed as

Signal TransductionAdiposityAnimalsDiet, High-FatEstrogensFemaleGlucoseInterleukin-18MiceMice, Inbred C57BLMuscle, SkeletalObesityOvariectomyReceptors, Interleukin-18EstrogensGlucoseInterleukin-18Receptors, Interleukin-18GenderIL-18Insulin resistanceObesity

Identifiers

PMID29699928
PMCPMC6001917
OpenAlexW2799697212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.