Evidence map›Paper›PMID 29699879›Full record

SynthesisBrazilian journal of otorhinolaryngology

Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.

Caroline Fernandes Rimoli, Regina Helena Garcia Martins, Daniele Cristina Catâneo, Rui Imamura, Antonio José Maria Catâneo

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Post-intubation laryngeal injuries: incidence, types, and outcomes in a tertiary setup.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Observational
  3. Multiple post-intubation tracheal granulomas presenting as stridor.Lung India : official organ of Indian Chest Society · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Voice Therapy in the Context of the COVID-19 Pandemic: Guidelines for Clinical Practice.Journal of voice : official journal of the Voice Foundation · 2021
    Review
  9. Terapia de voz en el contexto de la pandemia covid-19; recomendaciones para la práctica clínica.Journal of voice : official journal of the Voice Foundation · 2021
    Review
  10. Terapia Vocal No Contexto Da Pandemia Do Covid-19; Orientações Para A Prática Clínica.Journal of voice : official journal of the Voice Foundation · 2021
    Review
  11. Article
  12. Article
  13. Exuberant Intratracheal Granuloma.Case reports in otolaryngology · 2021
    Article
  14. Laryngeal Contact Ulcer.Head and neck pathology · 2020
    Article
  15. [Clinical analysis of 46 cases of female laryngeal contact granuloma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Caroline Fernandes RimoliUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil.
Regina Helena Garcia MartinsUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Botucatu, SP, Brazil. Electronic address: rmartins@fmb.unesp.br.
Daniele Cristina CatâneoUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Cirurgia, Botucatu, SP, Brazil.
Rui ImamuraUniversidade de São Paulo (USP), Departamento de Otorrinolaringologia, São Paulo, SP, Brazil.
Antonio José Maria CatâneoUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Cirurgia, Botucatu, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLaryngeal granulomas post intubation are benign but recurrent lesions. There is no consensus for its treatment.

objectiveTo describe the effectiveness of different treatment modalities for primary or recurrent laryngeal granulomas resulting from endotracheal intubation.

methodsSystematic review and proportional meta-analysis. Eligibility criteria - experimental or observational studies with at least five subjects. Outcomes studied - granuloma resolution, recurrence, and time for resolution. Databases used - Pubmed, Embase, Lilacs, and Cochrane. The Stats Direct 3.0.121 program was used.

resultsSix studies were selected, with 85 patients. The treatments registered were: antireflux therapy, speech therapy, anti-inflammatory drugs, steroids, antibiotics, zinc sulfate and surgery. 85 patients from six studies had primary treatment: surgery±associations (41 patients), resolution chance 75% (95% CI: 0.3-100%, I

conclusionThere is no evidence of high quality that proves the efficacy of any treatment for laryngeal granulomas resulting from endotracheal intubation.

Indexed as

Combined Modality TherapyGranuloma, LaryngealHumansIntubation, IntratrachealRecurrenceTime FactorsTreatment OutcomeGranulomasLaringeLarynxRevisão sistemáticaSystematic reviewTratamentoTreatment

Identifiers

PMID29699879
PMCPMC9442835
OpenAlexW2803048727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.