Evidence map›Paper›PMID 29699638›Full record

ArticleThe Kaohsiung journal of medical sciences2018

Increased frequency of AMP-activated protein kinase-positive spinal motor neurons after sciatic nerve injury in a mouse model.

Bao Qi, Gui-Jun Cao, Qing-Wei Li, Guo-Wu Chen, Xiao Liang, Yu-Zhong Wang, Chun-Yang Meng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bao QiDepartment of Graduate School, Jining Medical University, Jining, Shandong Province, China; Department of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Gui-Jun CaoDepartment of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Qing-Wei LiDepartment of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Guo-Wu ChenDepartment of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Xiao LiangDepartment of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Yu-Zhong WangDepartment of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Chun-Yang MengDepartment of Spine Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China. Electronic address: chunyangmeng16@163.com.
Affiliated Hospital of Jining Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of AMP-activated protein kinase (AMPK) in the regulation of energy metabolism and the control of skeletal muscle regeneration post injury has been described previously. It remains unknown whether this metabolic sensor plays a role in the mechanism of axonal regeneration post injury. In this study, we used a sciatic nerve crushed mouse model to detect the expression of AMPK in sciatic nerve and spinal motor neurons at 1 week, 2 weeks and 3 weeks after injury by immunofluorescence staining. Electrophysiological and histopathological studies were used to confirm the nerve injury and regeneration. Our results showed that frequency of AMPK-positive spinal motor neurons was significantly higher on day 7 after sciatic nerve crush (SNC) and peaked on day 14. No expression of AMPK was detected in axons of the sciatic nerve before and after the injury. Taken together, our study suggested a possible role of AMPK in the mechanism of motor nerve regeneration after injury.

Indexed as

Action PotentialsAMP-Activated Protein KinasesAnimalsAxonsDisease Models, AnimalGene ExpressionMaleMiceMice, Inbred C57BLMotor NeuronsNerve CrushNerve RegenerationSciatic NerveSciatic NeuropathySpinal CordTime FactorsAMP-Activated Protein KinasesAMP-Activated protein kinaseMotor neuronSciatic nerve injury

Identifiers

PMID29699638
PMCPMC12977102
OpenAlexW2784081845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.