ArticleJournal of neuroinflammation2018
Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G.
Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.Nature genetics · 2023Pooled it
- Immunoglobulin G in aging and cancer.Frontiers in immunology · 2026Review
- Immunoglobulin G N-glycosylation predicts long-term risk of ischemic stroke: a nested case-control study.Journal of translational medicine · 2025Article
- Glycomics in Human Diseases and Its Emerging Role in Biomarker Discovery.Biomedicines · 2025Review
- Profiling of IgG N-glycosylation for axial spondyloarthritis and other rheumatic diseases.Arthritis research & therapy · 2025Article
- Altered Pattern of Serum N-Glycome in Subarachnoid Hemorrhage and Cerebral Vasospasm.Journal of clinical medicine · 2025Article
- Immunoglobulin G N-Glycosylation and Inflammatory Factors: Analysis of Biomarkers for the Diagnosis of Moyamoya Disease.Journal of inflammation research · 2025Article
- Differences in IgG afucosylation between groups with and without carotid atherosclerosis.BMC cardiovascular disorders · 2024Article
- Bidirectional Two-Sample Mendelian Randomization Study of Immunoglobulin G N-Glycosylation and Senescence-Associated Secretory Phenotype.International journal of molecular sciences · 2024Article
- The association between plasma IgG N-glycosylation and neonatal hypoxic-ischemic encephalopathy: a case-control study.Frontiers in cellular neuroscience · 2024Article
- Predicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health.Frontiers in psychiatry · 2024Article
- Unravelling the genetic causality of immunoglobulin G N-glycans in ischemic stroke.Glycoconjugate journal · 2023Article
- Brain Glycogen: An Angel or a Devil for Ischemic Stroke?Neuroscience bulletin · 2023Article
- Association of IgG N-glycomics with prevalent and incident type 2 diabetes mellitus from the paradigm of predictive, preventive, and personalized medicine standpoint.The EPMA journal · 2023Article
- Translation and cross-cultural validation of a precision health tool, the Suboptimal Health Status Questionnaire-25, in Korean.Journal of global health · 2022Article
- IgG Glycosylation Profiling of Peripheral Artery Diseases with Lectin Microarray.Journal of clinical medicine · 2022Article
- Immunoglobulin G N-glycan, inflammation and type 2 diabetes in East Asian and European populations: a Mendelian randomization study.Molecular medicine (Cambridge, Mass.) · 2022Article
- Article
- Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine.The EPMA journal · 2022Article
- Glycomic biomarkers are instrumental for suboptimal health status management in the context of predictive, preventive, and personalized medicine.The EPMA journal · 2022Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGlycosylation significantly affects protein structure and function and thus participates in multiple physiologic and pathologic processes. Studies demonstrated that immunoglobulin G (IgG) N-glycosylation associates with the risk factors of ischemic stroke (IS), such as aging, obesity, dyslipidemia, type 2 diabetes, and hypertension.
methodsThe study aimed to investigate the association between IgG N-glycosylation and IS in a Chinese population. IgG glycome composition in patients with IS (n = 78) and cerebral arterial stenosis (CAS) (n = 75) and controls (n = 77) were analyzed by ultra-performance liquid chromatography.
resultsEleven initial glycans and 10 derived glycans in IgG glycome representing galactosylation, sialylation, and bisecting GlcNAc significantly differed between IS patients and CAS and healthy controls after controlling for gender, age, obesity, diabetes, hypertension, and dyslipidemia. Logistic regression models incorporating IgG glycan traits were able to distinguish IS from CAS (area under receiver-operator characteristic curves (AUC), 0.802; 95% confidence interval (CI), 0.732-0.872) and controls (AUC, 0.740; 95% CI, 0.661-0.819). The canonical correlation analysis indicated that initial N-glycan structures are significantly correlated with inflammation markers (r = 0.566, p < 0.001).
conclusionOur findings indicated that loss of galactose and sialic acid, as well as addition of bisecting GlcNAc, might involve in pro- or anti-inflammatory IgG functionality and further contribute to the pathogenesis of IS. IgG glycan profiles may be developed as clinical useful biomarkers for chronic disease in the future.
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Registered trials
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