ArticleAsian Pacific journal of cancer prevention : APJCP2018
Evaluating the Oncogenic and Tumor Suppressor Role of XPO5 in Different Tissue Tumor Types
Article in Asian Pacific journal of cancer prevention : APJCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Analysis of exportins expression unveils their prognostic significance in colon adenocarcinoma: insights from public databases.Discover oncology · 2025Article
- Prognostic significance of exportin-5 in hepatocellular carcinoma.World journal of gastrointestinal oncology · 2024Article
- microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis.Frontiers in oncology · 2020Review
- MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer.International journal of molecular sciences · 2019Article
- KIF5A Promotes Bladder Cancer ProliferationDisease markers · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In our recent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells. Similarly, there are studies to support the inhibitory role of XPO5 in cancers. In order to evaluate discrepancies in the expression levels of XPO5 in differential tumor types, we quantified the expression of XPO5 using gene expression RNA-seq data for several tumor types which were independently confirmed by immunohistochemistry in multiple organs cancer tissue microarray (TMAs) experiment. We found that while some tumors (Breast, Bladder, Lymph-node, Lung, Esophagus and Ovary) showed higher differences between normal and malignant tumors in XPO5 expression, there were tissues (Kidney and Brain) that have a significantly lower XPO5 expression in malignant tumors. We further studies these observations of overexpression and down-regulation of XPO5 in breast and kidney cancer cell lines and found that XPO5 might have a dual role in promoting or inhibiting tumor growth in different cancer tissue types.
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