ArticleThe Journal of clinical investigation1988
Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.
Article in The Journal of clinical investigation, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 81 citations in OpenAlex.
- Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.Molecular and cellular biochemistry · 2021Article
- Small Conductance CaFrontiers in physiology · 2021Article
- Study of the Expression Transition of Cardiac Myosin Using Polarization-Dependent SHG Microscopy.Biophysical journal · 2020Article
- A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity.Cardiovascular research · 2020Article
- Developmental increase in β-MHC enhances sarcomere length-dependent activation in the myocardium.The Journal of general physiology · 2019Article
- Length-dependent effects on cardiac contractile dynamics are different in cardiac muscle containing α- or β-myosin heavy chain.Archives of biochemistry and biophysics · 2013Article
- Transactivation in Drosophila of human enhancers by human transcription factors involved in congenital heart diseases.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The emerging genetic landscape underlying cardiac conduction system function.Birth defects research. Part A, Clinical and molecular teratology · 2011Review
- Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.The Journal of clinical investigation · 2011Article
- Return to the fetal gene program: a suggested metabolic link to gene expression in the heart.Annals of the New York Academy of Sciences · 2010Review
- Several common variants modulate heart rate, PR interval and QRS duration.Nature genetics · 2010Article
- Insights into human beta-cardiac myosin function from single molecule and single cell studies.Journal of cardiovascular translational research · 2009Review
- Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene.PloS one · 2007Article
- Return to the fetal gene program protects the stressed heart: a strong hypothesis.Heart failure reviews · 2007Review
- Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure.Journal of molecular and cellular cardiology · 2007Review
- Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes.BMC musculoskeletal disorders · 2006Article
- A 7.1 kbp beta-myosin heavy chain promoter, efficient for green fluorescent protein expression, probably induces lethality when overexpressing a mutated transforming growth factor-beta type II receptor in transgenic mice.Transgenic research · 2005Article
- Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.The Journal of clinical investigation · 1997Article
- Myosin heavy chain gene expression in human heart failure.The Journal of clinical investigation · 1997Article
- Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome.The Journal of clinical investigation · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have constructed and characterized two types of myosin heavy chain (MHC) cDNA clones (pHMHC2, pHMHC5) from a fetal human heart cDNA library. Comparison of the nucleotide and deduced amino acid sequences between pHMHC2 and pHMHC5 shows 95.1 and 96.2% homology, respectively. The carboxyl-terminal peptide and 3'-untranslated (3'-UT) regions are highly divergent and specific for these cDNA clones. By using the synthetic oligonucleotide probes that are complementary to the unique 3'-UT regions of these cDNA clones, we demonstrate that pHMHC2 is exclusively transcribed in the atrium, whereas the mRNA for pHMHC5 is predominantly expressed in the ventricle. This result indicates that pHMHC2 and pHMHC5 code for alpha- and beta-form MHCs, respectively. Furthermore, we show that beta-form MHC mRNA is expressed in adult atrium at a low level but scarcely expressed in fetal atrium. Finally, we demonstrate that MHC isozymic transition in pressure-overloaded atrium is, at least in part, regulated at a pretranslational level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.