ArticleAsian Pacific journal of cancer prevention : APJCP2018
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
Article in Asian Pacific journal of cancer prevention : APJCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Role of optical imaging in oral cancer and oral potentially malignant disorders: implications for oral submucous fibrosis.Frontiers in oral health · 2025Review
- Computational analysis of phytocompounds inHeliyon · 2024Article
- Analysis of transcriptome expression profiling data in oral leukoplakia and early and late‑stage oral squamous cell carcinoma.Oncology letters · 2023Article
- Relation of salivary MMP-8 with oral submucous fibrosis and oral squamous cell carcinoma: a cross sectional analytical study.BMJ open · 2022Article
- An Evaluation of the Prognosticative Value of Hyalinization in the Biological Behaviour of Oral Lesions Using Image Analysis.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Application of Texture and Fractal Dimension Analysis to Estimate Effectiveness of Oral Leukoplakia Treatment Using an Er:YAG Laser-A Prospective Study.Materials (Basel, Switzerland) · 2020Article
- Theoretical Background to Automated Diagnosing of Oral Leukoplakia: A Preliminary Report.Journal of healthcare engineering · 2020Article
- Analysis of collagen fibers in human gingival tissues using picrosirius red stain under polarized microscope.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Picrosirius red and MMP are capable of degrading extracellular matrix proteins, expressed in lesions such as squamous cell carcinomas. The present study was undertaken with an aim to analyze and compare changes in collagen using Picrosirius red staining under polarizing microscopy and immunohistochemical staining using anti MMP-13 in samples of oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. Materials and Methods: A total of 70 slides were prepared and divided into 3 groups. Group I comprised 10 slides of normal gingival tissue, Group II 40 slides of potentially malignant disorders and Group III 20 slides of well differentiated oral squamous cell carcinoma. Half the slides for each group were stained with Picrosirius red stain and the remainder with antibodies to MMP-13. Rerults: In Group II, MMP-13 connective tissue expression was greater in OSMF as compared to leukoplakia. Group III showed elevated expression among 70% of cases. Picrosirius red staining in Group II cases, showed higher staining Yellow-Orange andGreen-Yellow mature fibers in OSMF than leukoplakia cases while in Group III, 50% OSCC cases showed Green-yellow stained immature thin fibers. Conclusion: In future, therapeutic measures targeted against MMP-13 may inhibit collagenolysis to some extent and delay spread of tumors. An easy and reliable method to determine the state of the stroma in such cases may be Picrosirius red staining with polarizing microscopy.
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