Evidence map›Paper›PMID 29698872›Full record

ArticleEnvironmental research2018

A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort.

Catherine C Lerro, Rena R Jones, Hilde Langseth, Tom K Grimsrud, Lawrence S Engel, Andreas Sjödin, Hyoyoung Choo-Wosoba, Paul Albert, Mary H Ward

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  4. Review
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  6. Article
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  11. Review
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  13. Review
  14. A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to?International journal of environmental research and public health · 2022
    Review
  15. Article
  16. Article
  17. Epidemiology of Thyroid Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Catherine C LerroOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. Electronic address: lerrocc@mail.nih.gov.
Rena R JonesOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Hilde LangsethDepartment of Research, Institute of Population-Based Cancer Research, Cancer Registry of Norway, Oslo, Norway.
Tom K GrimsrudDepartment of Research, Institute of Population-Based Cancer Research, Cancer Registry of Norway, Oslo, Norway.
Lawrence S EngelDepartment of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, NC, USA.
Andreas SjödinDivision of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Hyoyoung Choo-WosobaBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Paul AlbertBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
National Cancer Institute · USCancer Registry of Norway · NOCenters for Disease Control and Prevention · USUniversity of North Carolina at Chapel Hill · US

Funding

Studies of Occupational CancerZIACP010120 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LAN, QING · 2009 to 2025
$34.4M
INVESTIGATIONS OF ENVIRONMENTAL EXPOSURES AND CANCERZ01CP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CANTOR, KENNETH · 1996 to 2008
$108k
Intramural CDC HHS CC999999Intramural NIH HHS Z01 CP010125Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

backgroundPolychlorinated biphenyls (PCBs) and organochlorine pesticides have been associated with altered thyroid hormone levels in humans, but their relationship with thyroid cancer is unknown.

methodsWe conducted a nested case-control study of thyroid cancer in the Norwegian Janus Serum Bank cohort using pre-diagnostic blood samples from 1972 to 1985. Incident thyroid cancer (n = 108) was ascertained through 2008. Controls were matched 2:1 by age, date of blood draw, gender, and county. We used gas chromatography/mass spectrometry to quantify 36 PCB congeners and metabolites of pesticides DDT, chlordane, hexachlorocyclohexane, and hexachlorobenzene. PCBs and pesticide metabolites were evaluated individually and summed by degree of chlorination and parent compound, respectively. Odds ratios (OR) and 95% confidence intervals (CI) were computed using conditional logistic regression per specified increase in lipid-adjusted concentration. We additionally stratified analyses by birth cohort (1923-1932, 1933-1942, 1943-1957).

resultsIncreasing concentration of DDT metabolites (OR

conclusionsEmissions of PCBs and OC pesticides varied over time. Different risk patterns by birth cohort suggest the potential importance of timing of exposure in thyroid cancer risk. Further evaluation of these associations is warranted.

Indexed as

Blood BanksEnvironmental PollutantsHydrocarbons, ChlorinatedPesticidesPolychlorinated BiphenylsThyroid NeoplasmsCase-Control StudiesEnvironmental ExposureFemaleHumansMaleNorwayEnvironmental PollutantsHydrocarbons, ChlorinatedPesticidesPolychlorinated BiphenylsChlordaneDDTOrganochlorinesPolychlorinated biphenylsThyroid cancer

Identifiers

PMID29698872
PMCPMC5999553
OpenAlexW2799930637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.