ReviewAgeing research reviews2018
Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility.
Review in Ageing research reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Maternal Lifetime Stress on Offspring Biological Aging: A Systematic Review and Meta-Analysis of Observational Studies.International journal of molecular sciences · 2026Pooled it
- DNA methylation-estimated phenotypes, telomere length, aging and risk of intracranial aneurysms: Evidence from genetic studies.IBRO neuroscience reports · 2026Article
- BAGE: a Bayesian framework for age prediction based on PBMC gene expression data.BMC bioinformatics · 2026Article
- Exercise training to preserve vitality capacity in ageing.Experimental physiology · 2026Review
- Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study.Scientific reports · 2025Article
- Invited Perspective: Decoding the Prenatal Epigenetic Symphony-The Journey of a Decade.Environmental health perspectives · 2023Article
- Epigenetic Age Acceleration Markers Are Associated With Physiologic Frailty and All-Cause Mortality in People With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus.Frontiers in genetics · 2022Article
- Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses.International journal of environmental research and public health · 2021Article
- The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.Nature communications · 2021Article
- Hallmarks of environmental insults.Cell · 2021Review
- Is your environment making you older? Molecular biomarkers and new approaches to investigate the influences of environmental chemicals through aging.La Medicina del lavoro · 2021Article
- Molecular basis of ageing in chronic metabolic diseases.Journal of endocrinological investigation · 2020Review
- Article
- Relationships of Long-Term Smoking and Moist Snuff Consumption With a DNA Methylation Age Relevant Smoking Index: An Analysis in Buccal Cells.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Article
- CancerClock: A DNA Methylation Age Predictor to Identify and Characterize Aging Clock in Pan-Cancer.Frontiers in bioengineering and biotechnology · 2019Article
- DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.Molecular cell · 2018Review
- Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome andAging · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. In this review, we discuss the existing literature regarding DNAm-age's molecular relationships in six major categories: animal model systems, cancer processes, cellular aging processes, immune system processes, metabolic processes, and nucleic acid processes. We also present perspectives regarding the future of DNAm-age research, including the need to translate a greater number of ongoing research efforts to experimental and animal model systems.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.