ArticleChest2018
Serum Chloride Levels Track With Survival in Patients With Pulmonary Arterial Hypertension.
Article in Chest, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- LRRC8A deficiency in vascular smooth muscle cells promotes STAT1/Calcrl/Ramp1 signaling to decrease blood pressure.Acta pharmacologica Sinica · 2026Article
- Assessment of the Relationship Between the Six-Minute Walk Test (6MWT) With Serum Chloride Level and Mean Pulmonary Arterial Pressure in Patients With Pulmonary Arterial Hypertension.Pulmonary circulation · 2025Article
- Association between serum chloride and prevalence of metabolic syndrome in the general U.S. adult population: evidence from NHANES 2011-2018.BMC endocrine disorders · 2025Article
- Functional Measures in Non-COPD Chronic Respiratory Diseases: A Systematic Review.Journal of clinical medicine · 2024Review
- Circulating biomarkers in pulmonary arterial hypertension: State-of-the-art review and future directions.JHLT open · 2024Review
- Association between serum chloride levels and estimated glomerular filtration rate among US adults: evidence from NHANES 1999-2018.International urology and nephrology · 2024Article
- L-Shaped Association of Serum Chloride Level With All-Cause and Cause-Specific Mortality in American Adults: Population-Based Prospective Cohort Study.JMIR public health and surveillance · 2023Article
- Serum chloride as a respiratory failure marker in amyotrophic lateral sclerosis.Frontiers in aging neuroscience · 2023Article
- Hypochloremia as a novel adverse prognostic factor in acute liver failure.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- Increased intracellular ClActa pharmacologica Sinica · 2022Article
- Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular ClActa pharmacologica Sinica · 2022Article
- Enteral Sodium Chloride Supplementation and Fluid Balance in Children Receiving Diuretics.Children (Basel, Switzerland) · 2022Article
- With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension.JACC. Basic to translational science · 2021Article
- Lower serum chloride concentrations are associated with increased risk of mortality in critically ill cirrhotic patients: an analysis of the MIMIC-III database.BMC gastroenterology · 2021Article
- Prevalence and Mortality of Hypochloremia Among Patients with Coronary Artery Disease: A Cohort Study.Risk management and healthcare policy · 2021Article
- Hypochloraemia and 30 day readmission rate in patients with acute decompensated heart failure.ESC heart failure · 2020Article
- The association between serum chloride levels and chronic kidney disease progression: a cohort study.BMC nephrology · 2020Observational
- Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2020Article
- "I don't get no respect": the role of chloride in acute kidney injury.American journal of physiology. Renal physiology · 2019Review
- Retrospective Evaluation of the Prevalence and Prognosis of Hypochloremia in Dogs and Cats.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSerum chloride is an important homeostatic biomarker in left heart failure, with significant prognostic implications. The impact of serum chloride in the long-term survival of patients with pulmonary arterial hypertension (PAH) is unknown. We tested whether serum chloride levels are associated with long-term survival in patients with PAH.
methodsWe included patients with idiopathic or heritable PAH who had a basic metabolic panel performed at the time of their diagnostic right heart catheterization. Laboratory results were recorded both at diagnosis and 6-month follow-up.
resultsWe included 277 patients, mean age 51 ± 18 years and 73% women, of whom 254 had a follow-up electrolyte determination at 6 months. Serum chloride was 102.9 ± 3.9 mM/L at diagnosis. A serum chloride ≤ 100 mM/L was noted in 65 (24%) and 53 (21%) patients at diagnosis and 6 months, respectively. Patients with serum chloride ≤ 100 mM/L at 6 months tracked with increase mortality when adjusted by age, sex, pulmonary vascular resistance, diuretics or prostacyclin analogs usage, and serum creatinine and sodium at 6 months (hazard ratio, 1.83; 95% CI, 1.11-3.00). This group of patients was older, with decreased functional capacity, had worse renal function, took more diuretics, had higher pulmonary artery wedge pressure but lower mean pulmonary artery pressure, transpulmonary gradient, and pulmonary vascular resistance.
conclusionsSerum chloride at 6 months from the PAH diagnosis is a strong and independent predictor of mortality in patients with idiopathic or heritable PAH, even after adjusting serum sodium, renal function, diuretic, and prostacyclin analog usage.
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