Evidence map›Paper›PMID 29698707›Full record

ArticleBrain, behavior, and immunity2018

Distinct characteristics of hippocampal pathogenic T

Eléonore Beurel, Jeffrey A Lowell, Richard S Jope

Open access · greenAbstract readComment
In one paragraph

Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Immunity in Rodent Models of Stress.Biological psychiatry · 2026
    Review
  5. Article
  6. The emerging role of T cells in depression.Frontiers in psychiatry · 2026
    Review
  7. Article
  8. Astrocyte-derived CCL5-mediated CCR5Science advances · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eléonore BeurelDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, United States; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United States. Electronic address: ebeurel@miami.edu.
Jeffrey A LowellDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, United States.
Richard S JopeDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, United States; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United States.
University of Miami · US

Funding

Th17 cells as a new therapeutic target for depressionR01MH104656 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEUREL, ELEONORE · 2015 to 2024
$3.8M
Adaptive immune system function in depressionR01MH095380 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI JOPE, RICHARD S. · 2012 to 2016
$1.9M
The microbiota, a possible link between Th17 cells and depressionR01MH110415 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEUREL, ELEONORE · 2017 to 2021
$1.5M
NIMH NIH HHS R01 MH095380NIMH NIH HHS R01 MH104656NIMH NIH HHS R01 MH110415
6 · The paper itself

Abstract

Increasing evidence indicates that multiple actions of the immune system are closely intertwined with the development of depression and subsequent recovery processes. One of these interactions is substantial evidence that the T

Indexed as

DepressionTh17 CellsAnimalsHelplessness, LearnedHippocampusMiceMice, KnockoutDepressionTh17

Identifiers

PMID29698707
PMCPMC6287768
OpenAlexW2802219761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.