ArticleToxicology in vitro : an international journal published in association with BIBRA2018
Transepidermal water loss and skin conductance as barrier integrity tests.
Article in Toxicology in vitro : an international journal published in association with BIBRA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- In vitro Evaluation of Hydroxypropyl-β-cyclodextrin Effects on Rhein Flux Across Microneedle-pretreated Skin.AAPS PharmSciTech · 2026Article
- Skin barrier dysfunction and correlation with the onset and progression of psoriasis.Frontiers in immunology · 2026Review
- The Impact of Vehicle Occlusivity on Skin Delivery and Activity of a Janus Kinase Inhibitor: Comparison of Oil-Based Formulations.Pharmaceutics · 2025Article
- Retention of nickel, cobalt and chromium in skin at conditions mimicking intense hand hygiene practices using water, soap, and hand-disinfectant in vitro.Journal of occupational medicine and toxicology (London, England) · 2024Article
- Observations on the Tritiated Water and TEWL Skin Integrity Tests: Relevance to In Vitro Permeation Testing (IVPT).Pharmaceutical research · 2024Article
- A Novel Approach for Dermal Application of Pranoprofen-Loaded Lipid Nanoparticles for the Treatment of Post-Tattoo Inflammatory Reactions.Pharmaceutics · 2024Article
- Evaluating the Irritant Factors of Silicone and Hydrocolloid Skin Contact Adhesives Using Trans-Epidermal Water Loss, Protein Stripping, Erythema, and Ease of Removal.ACS applied bio materials · 2024Article
- Development of a lip vermilion epithelium reconstruction model using keratinocytes from skin and oral mucosa.Histochemistry and cell biology · 2023Article
- Parallel evaluation of alternative skin barrier models and excised human skin for dermal absorption studies in vitro.Toxicology in vitro : an international journal published in association with BIBRA · 2023Article
- Combined Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Mesotherapy Protocol to Improve Skin Appearance and Epidermal Barrier Function: A Pilot Study.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The Contest of Nanoparticles: Searching for the Most Effective Topical Delivery of Corticosteroids.Pharmaceutics · 2023Article
- The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters.Life (Basel, Switzerland) · 2023Article
- Preparation of topical bimatoprost with enhanced skin infiltration andDrug delivery · 2022Article
- Microneedle and iontophoresis mediated delivery of methotrexate into and across healthy and psoriatic skin.International journal of pharmaceutics · 2022Article
- How many skin barriers haveth we: Percutaneous egression of ions?Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Review
- Topical and transdermal delivery with diseased human skin: passive and iontophoretic delivery of hydrocortisone into psoriatic and eczematous skin.Drug delivery and translational research · 2022Article
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- Preparation of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal Efficacy against Superficial Mycosis.Pharmaceutics · 2021Article
- Apremilast Microemulsion as Topical Therapy for Local Inflammation: Design, Characterization and Efficacy Evaluation.Pharmaceuticals (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In vitro skin permeation studies are commonly used in the risk assessment of toxic compound skin exposure. The present study examined the utility of transepidermal water loss (TEWL) and electrical conductance as barrier integrity tests before skin permeation studies in vitro using a large number of skin samples and fentanyl. TEWL and conductance of the skin samples were measured before the permeation experiments in Franz diffusion cells in vitro with a vapometer and low voltage application, respectively. The data were analyzed based on the in vitro permeation results and in vivo skin absorption information from the transdermal fentanyl product labels. The results showed poor correlations between TEWL and electrical conductance for the skin samples. Weak correlations between fentanyl delivery rate (flux x area) and TEWL and skin conductance were observed. For comparison, TEWL and conductance were also examined after skin perturbation with a syringe needle, and both TEWL and conductance values of the skin samples increased after the perturbation. The data suggest that either TEWL of 10 g/m
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