ArticlePloS one2018
Assessing the impact of environmental exposures and Cryptosporidium infection in cattle on human incidence of cryptosporidiosis in Southwestern Ontario, Canada.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses.Parasitology · 2021Pooled it
- A systematic review of waterborne and water-related disease in animal populations of Florida from 1999-2019.PloS one · 2021Pooled it
- Systematic review of modifiable risk factors shows little evidential support for most current practices in Cryptosporidium management in bovine calves.Parasitology research · 2020Pooled it
- Impacts of meteorological factors on zoonotic infections in domestic cat and dog populations: A scoping review of international evidence.One health (Amsterdam, Netherlands) · 2026Review
- Molecular characterization and phylogenetic analysis of cryptosporidium spp. in pediatric acute gastroenteritis: Epidemiological insights from northeastern Iran.New microbes and new infections · 2025Article
- Climate-sensitive zoonotic diseases transmissible by companion animals: A scoping review protocol.PloS one · 2025Article
- Article
- Environmental Factors Associated withPathogens (Basel, Switzerland) · 2023Review
- Cryptosporidium in human-animal-environment interphase at Adama and Asella areas of Oromia regional state, Ethiopia.BMC veterinary research · 2022Article
- Comparative evaluation of various diagnostic techniques for detection ofIranian journal of veterinary research · 2022Article
- Article
- Molecular characterization of Cryptosporidium isolates from humans in Ontario, Canada.Parasites & vectors · 2021Article
- An analecta of visualizations for foodborne illness trends and seasonality.Scientific data · 2020Article
- A One Health Approach to Tackle Cryptosporidiosis.Trends in parasitology · 2020Review
- Dairy Calves in Uruguay Are Reservoirs of Zoonotic Subtypes ofFrontiers in veterinary science · 2020Article
- Cryptosporidium spp.: Human incidence, molecular characterization and associated exposures in Québec, Canada (2016-2017).PloS one · 2020Article
- Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptosporidium is a waterborne parasite that causes diarrheal disease in humans and in cattle. Risk factors for human illness include contact with surface water such as lakes and rivers, exposure to contaminated municipal drinking water, as well as zoonotic transmission from livestock and agriculture. The objectives of this study are twofold: 1) to describe the temporal distribution of cryptosporidiosis in Southwestern Ontario; and 2) to determine the distribution of human cryptosporidiosis, in relation to exposures such as cryptosporidium positive cattle farms, weather events, and hydrological factors. Seasonal trends in 214 bovine and 87 human cases were assessed using regression models that predicted monthly case counts in relation to observed monthly case counts. A case-crossover approach was used to evaluate acute associations between daily environmental exposures, such as weather, hydrology, the presence of Cryptosporidium positive cattle farms within the region, and the risk of human Cryptosporidium infection. Annual seasonality was found for both human cases and bovine cases with human cases peaking in mid-summer and bovine cases peaking in late winter to early spring. Bovine cases that occurred 21 days prior to human cases were associated with a three-fold increase in the odds of human case occurrence. At both 9 and 14 days prior to human case onset, the odds of a human case increased twofold per 10-degree Celsius increase in air temperature. These results provide a preliminary hypothesis for the zoonotic transmission of cryptosporidiosis from cattle to humans via the environment and suggest that the timing of environmental conditions in relation to case occurrence is biologically plausible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.