ArticlePloS one2018
Stroke infarct volume estimation in fixed tissue: Comparison of diffusion kurtosis imaging to diffusion weighted imaging and histology in a rodent MCAO model.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
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- Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer's Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping.Biomolecules · 2024Article
- The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI.Frontiers in cellular neuroscience · 2024Article
- Optimization of quasi-diffusion magnetic resonance imaging for quantitative accuracy and time-efficient acquisition.Magnetic resonance in medicine · 2022Article
- Beyond Diffusion Tensor MRI Methods for Improved Characterization of the Brain after Ischemic Stroke: A Review.AJNR. American journal of neuroradiology · 2022Review
- NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment.Magnetic resonance in medicine · 2021Article
- Rapid microstructural plasticity in the cortical semantic network following a short language learning session.PLoS biology · 2021Article
- Article
- Mir-184 Contributes to Brain Injury Through Targeting PPAP2B Following Ischemic Stroke in Male Rats.Frontiers in molecular neuroscience · 2021Article
- Machine learning identifies stroke features between species.Theranostics · 2021Article
- Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Environmental Circadian Disruption Increases Stroke Severity and Dysregulates Immune Response.Journal of biological rhythms · 2020Article
- Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.Neurotoxicity research · 2020Article
- An Introduction to Kurtosis Fractional Anisotropy.AJNR. American journal of neuroradiology · 2019Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffusion kurtosis imaging (DKI) is a new promising MRI technique with microstructural sensitivity superior to conventional diffusion tensor (DTI) based methods. In stroke, considerable mismatch exists between the infarct lesion outline obtained from the two methods, kurtosis and diffusion tensor derived metrics. We aim to investigate if this mismatch can be examined in fixed tissue. Our investigation is based on estimates of mean diffusivity (MD) and mean (of the) kurtosis tensor (MKT) obtained using recent fast DKI methods requiring only 19 images. At 24 hours post stroke, rat brains were fixed and prepared. The infarct was clearly visible in both MD and MKT maps. The MKT lesion volume was roughly 31% larger than the MD lesion volume. Subsequent histological analysis (hematoxylin) revealed similar lesion volumes to MD. Our study shows that structural components underlying the MD/MKT mismatch can be investigated in fixed tissue and therefore allows a more direct comparison between lesion volumes from MRI and histology. Additionally, the larger MKT infarct lesion indicates that MKT do provide increased sensitivity to microstructural changes in the lesion area compared to MD.
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