ArticlePloS one2018
Clinical manifestations in infants and children with Mycoplasma pneumoniae infection.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04126304 (Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China), which is not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- A systematic review of the clinical features of pneumonia in children aged 5-9 years: Implications for guidelines and research.Journal of global health · 2022Pooled it
- A machine learning-based early in-hospital risk stratification model for severe mycoplasma pneumoniae pneumonia in children.Translational pediatrics · 2026Article
- Coinfection Patterns ofInternational journal of molecular sciences · 2026Article
- Unveiling metagenomic and metabolomic signatures in mild and severe pneumonia caused byMicrobial genomics · 2026Article
- From Respiratory Pathogen to Systemic Threat: RethinkingMicroorganisms · 2026Review
- Reactive Infectious Mucocutaneous Eruption (RIME) Associated withMicroorganisms · 2026Article
- Article
- The expression and clinical value ofTranslational pediatrics · 2026Article
- Clinical characteristics, predictive factors, and therapeutic outcomes of mycoplasma pneumoniae pneumonia with pleural effusion in children: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- A complex pediatric cervical lymphadenopathy: case report.AME case reports · 2026Article
- Community-Acquired Pneumonia Manifested by Acute Abdominal Pain: A Case Report.Case reports in infectious diseases · 2026Article
- Influence of Mycoplasma Resistance Genes on Pediatric Mycoplasma Pneumonia Treatment and Determinants for Second-line Antimicrobial Adjustment.Combinatorial chemistry & high throughput screening · 2026Article
- Comparative Analysis of Pathogen-Specific IgM Antibody and Nucleic Acid Detection in Patients with Respiratory Tract Infectionsin Northern Anhui, China: An Epidemiological Study.Infection and drug resistance · 2026Article
- Development of a Prediction Model for Severe PediatricInfection and drug resistance · 2026Article
- Reactive infectious mucocutaneous eruption: an increasingly encountered complication during periods of increasedASM case reports · 2025Article
- Double trouble:European heart journal. Case reports · 2025Article
- The Clinical Profile of PediatricMicroorganisms · 2025Article
- Article
- Antibiotic resistance and viral co-infection in children diagnosed with pneumonia caused by Mycoplasma pneumoniae admitted to Russian hospitals during October 2023-February 2024.BMC infectious diseases · 2025Article
- The role of IFN-γ/CXCL10 axis in Mycoplasma pneumonia infection.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMycoplasma pneumoniae is a common cause of community-acquired pneumonia in older children. Pulmonary and extra-pulmonary symptoms associated with M. pneumoniae infection are reported. M. pneumoniae is mainly epidemic in Denmark with the recurrence every 4-7th year.
aimsRetrospectively, to describe the epidemiology and clinical features, in infants and children, during the M. pneumoniae epidemic in 2010 and 2011.
methodsAll children under the age of 16 that were tested for M. pneumoniae during the period 01.02.2010-31.01.2012 were included. Medical charts, as well as radiological findings, were reviewed for all children with M. pneumoniae. A post-hoc analysis of viral co-infections was done on part of the cohort.
results134 of 746 children were tested positive for M. pneumoniae by PCR or serology. Positive tests were found in 65% of children seven years and older, in 30% of 2-6-year-olds and 4% of infants (less than two years of age). Viral co-infection was found in 27% of the tested samples. The clinical presentation was a cough, asthma-like symptoms and low-grade fever. Extra-pulmonary symptoms were common and presented as nausea/vomiting by 33% of the children and skin manifestations by 25%. 84% of the children had a chest x-ray taken, and there were positive radiological findings in 94% of these.
conclusionM. pneumoniae also affected infants and young children and symptoms were similar to infections with respiratory viruses, but severe LRTI were also seen. During an up-coming epidemic, assessment of extra-pulmonary manifestations can be helpful when diagnosing M. pneumoniae infections.
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