ReviewCurrent opinion in infectious diseases2018
When do co-infections matter?
Review in Current opinion in infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Risk factors for infection in older adults with home care: a mixed methods systematic review with meta-analysis.BMC public health · 2025Pooled it
- Systematic review and meta-analysis of Tuberculosis and COVID-19 Co-infection: Prevalence, fatality, and treatment considerations.PLoS neglected tropical diseases · 2024Pooled it
- Burden of intestinal protozoan parasites coinciding with Helicobacter pylori infection in patients with gastrointestinal symptoms.Gut pathogens · 2026Article
- Association ofJournal of tropical medicine · 2026Article
- Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease?Viruses · 2025Review
- Prevalence and Patterns of Enteric Co-Infections Among Individuals Presenting with Cholera-like Diarrheal Disease During Seasonal Cholera Outbreaks.Pathogens (Basel, Switzerland) · 2025Article
- Lower airway microbiota compositions and diversity among ventilator-associated pneumonia patients across COVID-19 epidemic phases: a retrospective study.Microbiology spectrum · 2025Article
- Effects of host sex, age and behaviour on co-infection patterns in a wild ungulate.Parasitology · 2025Article
- Contagious Caprine Pleuropneumonia: Seroprevalence and Risk Factors in Goats in Derashe Zone, Southern Ethiopia.Immunity, inflammation and disease · 2025Article
- Coinfection of hepatitis B, tuberculosis, and HIV/AIDS in Beijing from 2016 to 2023: a surveillance data analysis.BMC infectious diseases · 2025Article
- Prevalence and Outcomes of Infections in Critically-ill Paediatric Oncology Patients: A Retrospective Observation Study.Current pediatric reviews · 2025Observational
- Limitations of inflammatory biomarkers in differentiating patients with fungal pneumonia and bacterial co-infection.Current medical mycology · 2025Article
- Assessment of Human Taeniasis and Other Intestinal Parasites in Narok County, Kenya.Veterinary medicine international · 2025Article
- Mathematical modelling and analysis for the co-infection of viral and bacterial diseases: a systematic review protocol.BMJ open · 2024Article
- Spatial associations of Hansen's disease and schistosomiasis in endemic regions of Minas Gerais, Brazil.PLoS neglected tropical diseases · 2024Article
- The prevalence and immune response to coinfection by avian haemosporidians in wild Eurasian blackbirdsParasitology · 2024Article
- Prevalence ofMicroorganisms · 2024Article
- Seroepidemiological study on coinfection of toxoplasmosis and active tuberculosis in Northern Iran: a case control study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Coinfection frequency in water flea populations is a mere reflection of parasite diversity.Communications biology · 2024Article
- Validity of dried blood spot testing for sexually transmitted and blood-borne infections: A narrative systematic review.PLOS global public health · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewAdvances in diagnostic methods mean that co-infections are increasingly being detected in clinical practice, yet their significance is not always obvious. In parallel, basic science studies are increasingly investigating interactions between pathogens to try to explain real-life observations and elucidate biological mechanisms. RECENT
findingsCo-infections may be insignificant, detrimental, or even beneficial, and these outcomes can occur through multiple levels of interactions which include modulation of the host response, altering the performance of diagnostic tests, and drug-drug interactions during treatment. The harmful effects of chronic co-infections such as tuberculosis or Hepatitis B and C in association with HIV are well established, and recent studies have focussed on strategies to mitigate these effects. However, consequences of many acute co-infections are much less certain, and recent conflicting findings simply highlight many of the challenges of studying naturally acquired infections in humans. SUMMARY: Tackling these challenges, using animal models, or careful prospective studies in humans may prove to be worthwhile. There are already tantalizing examples where identification and treatment of relevant co-infections seems to hold promise for improved health outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.