Evidence map›Paper›PMID 29698124›Full record

ReviewJournal of palliative medicine2018

Palliative Care and Hospice Interventions in Decompensated Cirrhosis and Hepatocellular Carcinoma: A Rapid Review of Literature.

Sandhya K Mudumbi, Claire E Bourgeois, Nicholas A Hoppman, Catherine H Smith, Manisha Verma, Marie A Bakitas, Cynthia J Brown, Alayne D Markland

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of palliative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Guideline
  2. A closer look at quality of life in the hepatocellular carcinoma literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
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  14. Current Medical Treatment for Alcohol-Associated Liver Disease.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sandhya K Mudumbi1 Center for Palliative and Supportive Care, University of Alabama at Birmingham , Birmingham, Alabama.
Claire E Bourgeois4 University of Alabama at Birmingham School of Medicine , Birmingham, Alabama.
Nicholas A Hoppman5 Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Catherine H Smith6 Lister Hill Library of the Health Sciences, University of Alabama at Birmingham , Birmingham, Alabama.
Manisha Verma7 Division of Hepatology, Department of Transplantation, Einstein Healthcare Network , Philadelphia, Pennsylvania.
Marie A Bakitas1 Center for Palliative and Supportive Care, University of Alabama at Birmingham , Birmingham, Alabama.
Cynthia J Brown2 Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
Alayne D Markland2 Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.
University of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with decompensated cirrhosis (DC) and/or hepatocellular carcinoma (HCC) have a high symptom burden and mortality and may benefit from palliative care (PC) and hospice interventions.

objectiveOur aim was to search published literature to determine the impact of PC and hospice interventions for patients with DC/HCC.

methodsWe searched electronic databases for adults with DC/HCC who received PC, using a rapid review methodology. Data were extracted for study design, participant and intervention characteristics, and three main groups of outcomes: healthcare resource utilization (HRU), end-of-life care (EOLC), and patient-reported outcomes.

resultsOf 2466 results, eight were included in final results. There were six retrospective cohort studies, one prospective cohort, and one quality improvement study. Five of eight studies had a high risk of bias and seven studied patients with HCC. A majority found a reduction in HRU (total cost of hospitalization, number of emergency department visits, hospital, and critical care admissions). Some studies found an impact on EOLC, including location of death (less likely to die in the hospital) and resuscitation (less likely to have resuscitation). One study evaluated survival and found hospice had no impact and another showed improvement of symptom burden.

conclusionStudies included suggest that PC and hospice interventions in patients with DC/HCC reduce HRU, impact EOLC, and improve symptoms. Given the few number of studies, heterogeneity of interventions and outcomes, and high risk of bias, further high-quality research is needed on PC and hospice interventions with a greater focus on DC.

Indexed as

Practice Guidelines as TopicAdultAgedAged, 80 and overCarcinoma, HepatocellularFemaleHospice CareHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedPalliative CareProspective StudiesRetrospective StudiesTerminal Carecirrhosisliver diseasepalliative carerapid reviewsymptomsutilization

Identifiers

PMID29698124
PMCPMC6104656
OpenAlexW2801212795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.