Evidence map›Paper›PMID 29697848›Full record

ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2018

Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007-2008 and 2012-2014.

Manuela Carugati, Holly M Biggs, Michael J Maze, Robyn A Stoddard, Shama Cash-Goldwasser, Julian T Hertz, Jo E B Halliday, Wilbrod Saganda, Bingileki F Lwezaula, Rudovick R Kazwala and 4 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

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  18. Modeling the Impact of Seasonal Weather Variations on the Infectiology of Brucellosis.Computational and mathematical methods in medicine · 2020
    Article
  19. Fever, bacterial zoonoses, and One Health in sub-Saharan Africa.Clinical medicine (London, England) · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 5 countries.

Manuela CarugatiDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
Holly M BiggsDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
Michael J MazeKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Robyn A StoddardCenters for Disease Control and Prevention, Bacterial Special Pathogens Branch, Atlanta, GA, USA.
Shama Cash-GoldwasserKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Julian T HertzDuke Global Health Institute, Duke University, Durham, NC, USA.
Jo E B HallidayBoyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
Wilbrod SagandaMawenzi Regional Referral Hospital, Moshi, Tanzania.
Bingileki F LwezaulaMawenzi Regional Referral Hospital, Moshi, Tanzania.
Rudovick R KazwalaSokoine University of Agriculture, Morogoro, Tanzania.
Sarah CleavelandBoyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
Venance P MaroKilimanjaro Christian Medical Centre, Moshi, Tanzania.
Matthew P RubachDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
John A CrumpDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
Duke University · USKilimanjaro Christian Medical Centre · TZSt. Francis Referral Hospital · TZAzienda Ospedaliera San Gerardo · ITCenters for Disease Control and Prevention · USDuke Institute for Health Innovation · USDuke Medical Center · USGlasgow Centre for Population Health · GBSokoine University of Agriculture · TZUniversity of Glasgow · GBUniversity of Otago · NZ

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
University of California Global Health Institute Program for Fellows and ScholarsR25TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COHEN, CRAIG R, STRATHDEE, STEFFANIE A. · 2012 to 2017
$6.4M
Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3M
International Clinical Trials UnitU01AI062563 · NIAID · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2007
$4.0M
Investigating Febrile Deaths in Tanzania (INDITe)R01AI121378 · NIAID · DUKE UNIVERSITY · PI RUBACH, MATTHEW P · 2016 to 2020
$2.7M
The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: UnderR01TW009237 · FIC · DUKE UNIVERSITY · PI CRUMP, JOHN ANDREW · 2011 to 2014
$1.7M
Viral Zoonoses and Severe Febrile Illness in Northern TanzaniaK23AI116869 · NIAID · DUKE UNIVERSITY · PI RUBACH, MATTHEW P · 2016 to 2020
$896k
Biotechnology and Biological Sciences Research Council BB/J010367/1Biotechnology and Biological Sciences Research Council BB/L017679Biotechnology and Biological Sciences Research Council BB/L018845Biotechnology and Biological Sciences Research Council BB/L018845/1Biotechnology and Biological Sciences Research Council BB/L018926Biotechnology and Biological Sciences Research Council BB/L018926/1FIC NIH HHS R01 TW009237FIC NIH HHS R24 TW007988FIC NIH HHS R25 TW009337FIC NIH HHS R25 TW009343NIAID NIH HHS K23 AI116869NIAID NIH HHS R01 AI121378NIAID NIH HHS T32 AI007392NIAID NIH HHS U01 AI062563
6 · The paper itself

Abstract

Background: Brucellosis causes substantial morbidity among humans and their livestock. There are few robust estimates of the incidence of brucellosis in sub-Saharan Africa. Using cases identified through sentinel hospital surveillance and health care utilization data, we estimated the incidence of brucellosis in Moshi Urban and Moshi Rural Districts, Kilimanjaro Region, Tanzania, for the periods 2007-2008 and 2012-2014. Methods: Cases were identified among febrile patients at two sentinel hospitals and were defined as having either a 4-fold increase in Brucella microscopic agglutination test titres between acute and convalescent serum or a blood culture positive for Brucella spp. Findings from a health care utilization survey were used to estimate multipliers to account for cases not seen at sentinel hospitals. Results: Of 585 patients enrolled in the period 2007-2008, 13 (2.2%) had brucellosis. Among 1095 patients enrolled in the period 2012-2014, 32 (2.9%) had brucellosis. We estimated an incidence (range based on sensitivity analysis) of brucellosis of 35 (range 32-93) cases per 100 000 persons annually in the period 2007-2008 and 33 (range 30-89) cases per 100 000 persons annually in the period 2012-2014. Conclusions: We found a moderate incidence of brucellosis in northern Tanzania, suggesting that the disease is endemic and an important human health problem in this area.

Indexed as

AdolescentAgglutination TestsAnimalsAnti-Bacterial AgentsBrucellaBrucellosisChildChild, PreschoolDoxycyclineFemaleFeverHealth SurveysHumansIncidenceInfantInfant, NewbornAnti-Bacterial AgentsDoxycycline

Identifiers

PMID29697848
PMCPMC5961162
OpenAlexW2796400481

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.