ArticleGenome biology and evolution2018
Signatures of DNA Methylation across Insects Suggest Reduced DNA Methylation Levels in Holometabola.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 125 citations in OpenAlex.
- DNA methylation dynamics associated with seasonal wing plasticity of Bicyclus anynana butterflies.Molecular biology and evolution · 2026Article
- Sex-biased DNA methylation in small hive beetles (Aethina tumida).Insect molecular biology · 2026Article
- Arms races between selfish genetic elements and their host defence in termites.Nature communications · 2026Article
- A Chromosome-Level Genome Assembly and Resequencing Data Reveal Low DNA Methylation and Reduced Diversity in the Solitary Bee Pollinator Osmia cornuta.Genome biology and evolution · 2026Article
- Article
- Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes.Nature genetics · 2025Article
- Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Whole organism integrated DNA methylation and transcriptomics analysis of butterfly metamorphosis.Scientific reports · 2025Article
- Evolutionary Consequences of Unusually Large Pericentric TE-rich Regions in the Genome of a Neotropical Fig Wasp.Genome biology and evolution · 2025Article
- When and how do 17-year periodical cicada nymphs decide to emerge? A field test of the 4-year-gate hypothesis.Proceedings. Biological sciences · 2025Article
- The Genome Architecture of the Copepod Eurytemora carolleeae - the Highly Invasive Atlantic Clade of the Eurytemoraaffinis Species Complex.Genomics, proteomics & bioinformatics · 2024Article
- Dengue virus preferentially uses human and mosquito non-optimal codons.Molecular systems biology · 2024Article
- Depletion of CpG dinucleotides in bacterial genomes may represent an adaptation to high temperatures.NAR genomics and bioinformatics · 2024Article
- A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector.Npj viruses · 2024Article
- Gene body methylation evolves during the sustained loss of parental care in the burying beetle.Nature communications · 2024Article
- The Patterns of Codon Usage between Chordates and Arthropods are Different but Co-evolving with Mutational Biases.Molecular biology and evolution · 2024Article
- GC Content Across Insect Genomes: Phylogenetic Patterns, Causes and Consequences.Journal of molecular evolution · 2024Article
- Article
- Epigenetic Diversity Underlying Seasonal and Annual Variations in Brown Planthopper (BPH) Populations as Revealed by Methylation- sensitive Restriction Assay.Current genomics · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been experimentally shown that DNA methylation is involved in the regulation of gene expression and the silencing of transposable element activity in eukaryotes. The variable levels of DNA methylation among different insect species indicate an evolutionarily flexible role of DNA methylation in insects, which due to a lack of comparative data is not yet well-substantiated. Here, we use computational methods to trace signatures of DNA methylation across insects by analyzing transcriptomic and genomic sequence data from all currently recognized insect orders. We conclude that: 1) a functional methylation system relying exclusively on DNA methyltransferase 1 is widespread across insects. 2) DNA methylation has potentially been lost or extremely reduced in species belonging to springtails (Collembola), flies and relatives (Diptera), and twisted-winged parasites (Strepsiptera). 3) Holometabolous insects display signs of reduced DNA methylation levels in protein-coding sequences compared with hemimetabolous insects. 4) Evolutionarily conserved insect genes associated with housekeeping functions tend to display signs of heavier DNA methylation in comparison to the genomic/transcriptomic background. With this comparative study, we provide the much needed basis for experimental and detailed comparative analyses required to gain a deeper understanding on the evolution and function of DNA methylation in insects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.