Evidence map›Paper›PMID 29697049›Full record

ArticleeLife2018

Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis.

Courtney W Stairs, Laura Eme, Sergio A Muñoz-Gómez, Alejandro Cohen, Graham Dellaire, Jennifer N Shepherd, James P Fawcett, Andrew J Roger

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. EPR characterization of a metal-binding site in RquA.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Evolutionary cell biology comes of age.Journal of cell science · 2025
    Article
  8. A diverse Palaeoproterozoic microbial ecosystem implies early eukaryogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Courtney W StairsCentre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.ORCID http://orcid.org/0000-0001-6650-0970
Laura EmeCentre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.
Sergio A Muñoz-GómezCentre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.
Alejandro CohenProteomics Core Facility, Life Sciences Research Institute, Dalhousie University, Halifax, Canada.
Graham DellaireDepartment of Pathology, Dalhousie University, Halifax, Canada.ORCID http://orcid.org/0000-0002-3466-6316
Jennifer N ShepherdDepartment of Chemistry and Biochemistry, Gonzaga University, Spokane, United States.
James P FawcettProteomics Core Facility, Life Sciences Research Institute, Dalhousie University, Halifax, Canada.
Andrew J RogerCentre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.ORCID http://orcid.org/0000-0003-1370-9820

Funding

Elucidation and Regulation of Rhodoquinone Biosynthesis in Rhodospirillum rubrumR15GM096398 · NIGMS · GONZAGA UNIVERSITY · PI SHEPHERD, JENNIFER NIVEN · 2011 to 2011
$241k
CIHR MOP 142349CIHR MOP 341174NIGMS NIH HHS R15 GM096398NIH HHS 1R15GM096398-01
6 · The paper itself

Abstract

Under hypoxic conditions, some organisms use an electron transport chain consisting of only complex I and II (CII) to generate the proton gradient essential for ATP production. In these cases, CII functions as a fumarate reductase that accepts electrons from a low electron potential quinol, rhodoquinol (RQ). To clarify the origins of RQ-mediated fumarate reduction in eukaryotes, we investigated the origin and function of

Indexed as

Adaptation, BiologicalAnaerobiosisGene Transfer, HorizontalBacteriaElectron Transport Complex IIEukaryotaFumaratesGenetic VariationOxidation-ReductionPhylogenyUbiquinoneElectron Transport Complex IIFumaratesrhodoquinoneUbiquinoneanaerobicevolutionevolutionary biologygenomicsmitochondriaprotistsPygsuiarhodoquinone

Identifiers

PMID29697049
PMCPMC5953543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.