SynthesisHuman brain mapping2018
The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task.
Synthesis in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03965247 (The Effects of Short-term Lithium Administration on Striatal Reward Processing and Prefrontal Control During Reappraisal in Healthy Volunteers), which is not on this map. Cited by 230 papers, 13 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Short-term Lithium Administration on Striatal Reward Processing and Prefrontal Control During Reappraisal in Healthy Volunteers
Who cites it
230 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- The effects of childhood adversity: Two specific neural patterns.Neuroscience and biobehavioral reviews · 2025Pooled it
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- A meta-analysis of the neural substrates of monetary reward anticipation and outcome in alcohol use disorder.Human brain mapping · 2023Pooled it
- Clarifying the role of Cortico-Cortical and Amygdalo-Cortical brain dysconnectivity associated with Conduct Problems.NeuroImage. Clinical · 2023Pooled it
- Risk-taking in the human brain: An activation likelihood estimation meta-analysis of the balloon analog risk task (BART).Human brain mapping · 2022Pooled it
- Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.NeuroImage · 2022Pooled it
- Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task.Translational psychiatry · 2022Pooled it
- "Wanting" versus "needing" related value: An fMRI meta-analysis.Brain and behavior · 2022Pooled it
- Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping.Clinical psychology review · 2022Pooled it
- Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.Clinical psychology review · 2021Pooled it
- A voxel-wise meta-analysis of task-based functional MRI studies on impaired gain and loss processing in adults with addiction.Journal of psychiatry & neuroscience : JPN · 2021Pooled it
- Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies.PloS one · 2021Pooled it
- Spatial migration of human reward processing with functional development: Evidence from quantitative meta-analyses.Human brain mapping · 2020Pooled it
- Subacute effects of ketamine on neural correlates of reward processing.Translational psychiatry · 2026Trial
- Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial.Nature medicine · 2026Trial
- Opioidergic modulation of monetary incentive delay fMRI responses.Psychopharmacology · 2025Trial
- Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- A randomized placebo controlled trial demonstrates the effect of dl-methylephedrine on brain functions is weaker than that of pseudoephedrine.Scientific reports · 2024Trial
- Amplification of positivity for depression and anxiety: Neural prediction of treatment response.Behaviour research and therapy · 2024Trial
- A randomized controlled experimental medicine study of ghrelin in value-based decision making.The Journal of clinical investigation · 2023Trial
170 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The processing of rewards and losses are crucial to everyday functioning. Considerable interest has been attached to investigating the anticipation and outcome phases of reward and loss processing, but results to date have been inconsistent. It is unclear if anticipation and outcome of a reward or loss recruit similar or distinct brain regions. In particular, while the striatum has widely been found to be active when anticipating a reward, whether it activates in response to the anticipation of losses as well remains ambiguous. Furthermore, concerning the orbitofrontal/ventromedial prefrontal regions, activation is often observed during reward receipt. However, it is unclear if this area is active during reward anticipation as well. We ran an Activation Likelihood Estimation meta-analysis of 50 fMRI studies, which used the Monetary Incentive Delay Task (MIDT), to identify which brain regions are implicated in the anticipation of rewards, anticipation of losses, and the receipt of reward. Anticipating rewards and losses recruits overlapping areas including the striatum, insula, amygdala and thalamus, suggesting that a generalised neural system initiates motivational processes independent of valence. The orbitofrontal/ventromedial prefrontal regions were recruited only during the reward outcome, likely representing the value of the reward received. Our findings help to clarify the neural substrates of the different phases of reward and loss processing, and advance neurobiological models of these processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.