ArticleCytotechnology2018
In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes.
Article in Cytotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Effects of Strawberry Tree (Toxics · 2024Article
- Article
- Protective Effects ofInternational journal of molecular sciences · 2023Article
- Use of Strawberry Tree (Foods (Basel, Switzerland) · 2022Review
- Variation in Population and Solvents as Factors Determining the Chemical Composition and Antioxidant Potential ofMolecules (Basel, Switzerland) · 2022Article
- Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection.Antibiotics (Basel, Switzerland) · 2022Review
- Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Plants (Basel, Switzerland) · 2021Article
- Effects of Itxasol© Components on Gene Expression in Bacteria Related to Infections of the Urinary Tract and to the Inflammation Process.International journal of molecular sciences · 2021Review
- A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation.Molecules (Basel, Switzerland) · 2021Review
- Arbutin suppresses osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway.FEBS open bio · 2021Article
- The Effect of Arbutin on The Expression of Tumor SuppressorCell journal · 2021Article
- Natural-Based Antioxidant Extracts as Potential Mitigators of Fruit Browning.Antioxidants (Basel, Switzerland) · 2020Article
- Protective effect of leaf extract ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Arbutin promotes MC3T3‑E1 mouse osteoblast precursor cell proliferation and differentiation via the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strawberry tree (Arbutus unedo L.) leaves have long been used in the traditional medicine of the Mediterranean region. One of their most bioactive constituents is the glycoside arbutin, whose presence makes A. unedo suitable as a potential substitute for bearberry [Arctostaphylos uva ursi (L.) Spreng] leaves, an herbal preparation widely used for treating urinary tract infections. The safety and biocompatibility of strawberry tree water leaf extract have not yet been documented well. This study estimated arbutin content in strawberry tree water leaf extract (STE) using high performance liquid chromatography. Furthermore, we performed an in vitro safety assessment of the 24 h exposure to three presumably non-toxic concentrations of standardized STE and arbutin in human peripheral blood lymphocytes using the apoptosis/necrosis assay, the alkaline comet assay, and the cytokinesis-block micronucleus cytome assay. The STE was also tested for total antioxidant capacity and lipid peroxidation. At a concentration corresponding to the maximum allowable daily intake of arbutin, the tested extract was not cytotoxic, had a negligible potential for causing primary DNA damage and even hindered micronuclei formation in lymphocytes. It also showed a valuable antioxidant capacity, and did not exert marked lipid peroxidation. These promising results represent a solid frame for further development of STE-based herbal preparations. Although arbutin generally had a low DNA damaging potential, the slowing down of lymphocyte proliferation observed after 24 h of exposure points to a cytostatic effect, which merits further research.
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