SynthesisClinical oral investigations2018
Treatment modalities for burning mouth syndrome: a systematic review.
Synthesis in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A systematic review of treatment for patients with burning mouth syndrome.Cephalalgia : an international journal of headache · 2022Pooled it
- Effects of topically applied liquid N-acetylcysteine for the management of burning mouth syndrome.Scientific reports · 2025Trial
- Comparison of Clonazepam and Tongue Protector in the Treatment of Burning Mouth Syndrome.International journal of environmental research and public health · 2022Trial
- Analysis of pain prognosis, medication efficacy, treatment willingness and influencing factors in patients with burning mouth syndrome: a cross-sectional survey.BMC oral health · 2025Article
- Challenges of Diagnosis and Management of Burning Mouth Syndrome: A Literature Review.Current aging science · 2025Review
- Article
- A review of psychocutaneous disorders from a psychotherapeutic perspective-Toolkit for the dermatologist.Skin health and disease · 2023Review
- The efficacy of alpha-lipoic acid in the management of burning mouth syndrome: An updated systematic review of randomized controlled clinical trials.Health science reports · 2023Article
- The influence of intolerance of uncertainty on the correlation between the severity of symptoms and satisfaction with oral state in patients with burning mouth syndrome.Clinical oral investigations · 2022Article
- Efficacy of alpha-lipoic acid in patients with burning mouth syndrome compared to that of placebo or other interventions: a systematic review with meta-analyses.Journal of dental anesthesia and pain medicine · 2022Review
- Comparison of Dental Benzodiazepine Prescriptions From the U.S., England, and Australia From 2013 to 2018.American journal of preventive medicine · 2021Article
- Photobiomodulation Therapy in the Management of Burning Mouth Syndrome: Morphological Variations in the Capillary Bed.Dentistry journal · 2020Article
- Chronic orofacial pain.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Current management strategies for the pain of elderly patients with burning mouth syndrome: a critical review.BioPsychoSocial medicine · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn the burning mouth syndrome (BMS), patients experience a burning sensation in the oral cavity with no associated injury or clinical manifestation. The etiology of this condition is still poorly understood, and therefore, treatment is challenging. The aim of this study is to perform a systematic review of treatment possibilities described in the literature for BMS. MATERIALS AND
methodsPubMed, Embase, and SciELO databases were searched for randomized clinical trials published between 1996 and 2016.
resultsFollowing application of inclusion and exclusion criteria, 29 papers were analyzed and divided into five subcategories according to the type of treatment described: antidepressants, alpha-lipoic acid, phytotherapeutic agents, analgesic and anti-inflammatory agents, and non-pharmacological therapies. In each category, the results found were compared with regard to the methodology employed, sample size, assessment method, presence or absence of adverse effects, and treatment outcomes.
conclusionsThe analysis revealed that the use of antidepressants and alpha-lipoic acid has been showing promising results; however, more studies are necessary before we can have a first-line treatment strategy for patients with BMS. CLINICAL RELEVANCE: To review systematically the literature about Burning Mouth Syndrome treatment may aid the clinicians to choose the treatment modality to improve patients symptoms based on the best evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.